Literature DB >> 6653721

Adenosine activates a potassium conductance in guinea-pig atrial heart muscle.

G Jochem, H Nawrath.   

Abstract

Adenosine shortens the action potential and diminishes the force of contraction in guinea-pig left atria. These effects may be brought about by the activation of a potassium conductance. This assumption is supported by voltage clamp and 42K release experiments.

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Year:  1983        PMID： 6653721     DOI： 10.1007/BF01990096

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  Inhibition of slow action potentials of guinea pig atrial muscle by adenosine: a possible effect on Ca2+ influx.

Authors:  J Schrader; R Rubio; R M Berne
Journal:  J Mol Cell Cardiol       Date:  1975-06       Impact factor: 5.000

2.  Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart?

Authors:  H Nawrath
Journal:  Nature       Date:  1977-05-05       Impact factor: 49.962

3.  Adenosine as inhibitor of myocardial effects of catecholamines.

Authors:  J Schrader; G Baumann; E Gerlach
Journal:  Pflugers Arch       Date:  1977-11-25       Impact factor: 3.657

4.  Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium.

Authors:  H Nawrath
Journal:  Nature       Date:  1976-08-05       Impact factor: 49.962

5.  An analysis of the action of ATP and related compounds on membrane current and tension components in bullfrog atrial muscle.

Authors:  M Goto; A Yatani; Y Tsuda
Journal:  Jpn J Physiol       Date:  1977

6.  On the mechanism of the negative inotropic effect of acetylcholine.

Authors:  R Ten Eick; H Nawrath; T F McDonald; W Trautwein
Journal:  Pflugers Arch       Date:  1976-02-24       Impact factor: 3.657

7.  Saturable binding of adenosine to the dog heart microsomal fraction: competitive inhibition by aminophylline.

Authors:  P Dutta; S J Mustafa
Journal:  J Pharmacol Exp Ther       Date:  1979-12       Impact factor: 4.030

8.  Cardiac muscarinic cholinergic receptors. Biochemical identification and characterization.

Authors:  J Z Fields; W R Roeske; E Morkin; H I Yamamura
Journal:  J Biol Chem       Date:  1978-05-10       Impact factor: 5.157

9.  Inhibitory action of adenosine on histamine- and dopamine-stimulated cardiac contractility and adenylate cyclase in guinea pigs.

Authors:  G Baumann; J Schrader; E Gerlach
Journal:  Circ Res       Date:  1981-02       Impact factor: 17.367

10.  Evidence for an adenosine receptor on the surface of dog coronary myocytes.

Authors:  R A Olsson; C J Davis; E M Khouri; R E Patterson
Journal:  Circ Res       Date:  1976-07       Impact factor: 17.367
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  18 in total

1.  Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.

Authors:  H von der Leyen; W Schmitz; H Scholz; J Scholz; M J Lohse; U Schwabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-08       Impact factor: 3.000

2.  Adrenoceptor-mediated effects on calcium channel currents are antagonized by 5'-(N-ethyl)-carboxamido-adenosine in guinea-pig atrial cells.

Authors:  U Jahnel; H Nawrath; R Ochi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-05       Impact factor: 3.000

3.  Role of guanine nucleotide-binding protein in the regulation by adenosine of cardiac potassium conductance and force of contraction. Evaluation with pertussis toxin.

Authors:  M Böhm; R Brückner; J Neumann; W Schmitz; H Scholz; J Starbatty
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-04       Impact factor: 3.000

4.  Characterization of the K(+)-channel-coupled adenosine receptor in guinea pig atria.

Authors:  H Tawfik-Schlieper; K N Klotz; V A Kreye; U Schwabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-12       Impact factor: 3.000

Review 5.  Selective updates on mechanisms of action of positive inotropic agents.

Authors:  G Grupp
Journal:  Mol Cell Biochem       Date:  1987-08       Impact factor: 3.396

6.  [Cardiac effects of adenosine. Mechanism of action, pathophysiologic and clinical significance].

Authors:  M Böhm
Journal:  Klin Wochenschr       Date:  1987-06-01

7.  Antagonism of novel inotropic agents at A1 adenosine receptors and m-cholinoceptors in human myocardium.

Authors:  M Ungerer; M Böhm; R H Schwinger; E Erdmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-06       Impact factor: 3.000

8.  Pertussis toxin prevents adenosine receptor- and m-cholinoceptor-mediated sinus rate slowing and AV conduction block in the guinea-pig heart.

Authors:  M Böhm; W Schmitz; H Scholz; A Wilken
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989 Jan-Feb       Impact factor: 3.000

9.  Characterization of adenosine receptors in intact cultured heart cells.

Authors:  D el-Ani; K A Jacobson; A Shainberg
Journal:  Biochem Pharmacol       Date:  1994-08-17       Impact factor: 5.858

10.  Evidence against a role of nitric oxide in the indirect negative inotropic-effect of M-cholinoceptor stimulation in human ventricular myocardium.

Authors:  H Kilter; O Lenz; K La Rosée; M Flesch; R H Schwinger; M Mädge; F Kuhn-Regnier; M Böhm
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-09       Impact factor: 3.000
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