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Literature DB >> 6653664

Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: are there common or different sites of action?

Abstract

Slices of rabbit caudate nucleus were preincubated with [3H]dopamine then superfused and stimulated electrically. Baclofen, GABA and gabapentin 10(-4) and 10(-3) mol/l reduced the stimulation-evoked overflow of tritium in a similar manner. The effects of the substances were reinvestigated while one of them was present in a high concentration throughout the superfusion. These interaction experiments showed that baclofen and GABA have a common presynaptic site of action which is different from that of gabapentin.

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Year: 1983 PMID： 6653664 DOI： 10.1016/0014-2999(83)90425-9

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

16 in total

Review 1. Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function?

Authors: A Galvan; M Kuwajima; Y Smith
Journal: Neuroscience Date: 2006-10-23 Impact factor: 3.590

9. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin.

Authors: B Brawek; M Löffler; D J Dooley; A Weyerbrock; T J Feuerstein
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2007-12-12 Impact factor: 3.000

10. Facilitation of amphetamine-induced hypothermia in mice by GABA agonists and CCK-8.

Authors: G Boschi; N Launay; R Rips
Journal: Br J Pharmacol Date: 1991-04 Impact factor: 8.739

Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: are there common or different sites of action?

Review 1. Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function?

2. Permeation and systemic absorption of R- and S-baclofen across the nasal mucosa.

3. Structural requirement of the calcium-channel subunit alpha2delta for gabapentin binding.

4. The inadequacy of the reductionist approach in discovering new therapeutic agents against complex diseases.

5. α2δ-1 signaling in nucleus accumbens is necessary for cocaine-induced relapse.

Review 6. GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates.

7. Effect of chloral hydrate on in vivo KCl-induced striatal dopamine release in the rat.

Review 8. Gabapentin. A review of its pharmacological properties and clinical potential in epilepsy.

9. Differential modulation of K(+)-evoked (3)H-neurotransmitter release from human neocortex by gabapentin and pregabalin.

10. Facilitation of amphetamine-induced hypothermia in mice by GABA agonists and CCK-8.