Long-term clorgyline treatment antagonizes the eating and motor function responses to m-chlorophenylpiperazine.

Treatment for 21 days but not 3 days with clorgyline, a selective monoamine oxidase type A inhibitor with antidepressant effects, causes significant escape from m-chlorophenylpiperazine's effects on food intake, sedation level and induction of limb movements, but sensitizes rats to ejaculation. These findings support the prior reports of functional serotonin pathway adaptational changes in the motor system in response to antidepressant treatment and extend these findings to serotonin pathways involved in eating behavior.