Detection of lacrimal gland infiltration on routine bone scintigraphy.

We report a bone scan finding of bilaterally and symmetrically increased uptake at the lateral orbital rims in a patient with disseminated Hodgkin's disease. Computerized axial tomography (CT) demonstrated lacrimal gland enlargement, presumably due to infiltration by Hodgkin's disease. Both the radionuclide bone scan and CT findings, as well as the other physical and radiographic manifestations of Hodgkin's disease, resolved after chemotherapy. Infiltration by Hodgkin's lymphoma is a rare cause of lacrimal gland enlargement. We believe that this pattern of uptake on a routine bone scan should alert the physician to possible lacrimal gland disease, which could then be more definitively evaluated by CT examination.