Literature DB >> 6652613

Nonrandom chromosomal changes in untreated retinoblastomas.

W F Benedict, A Banerjee, C Mark, A L Murphree.   

Abstract

The karyotypic patterns of 15 retinoblastomas were examined. Five tumors were found to have two distinct stem lines and, therefore, the chromosomal patterns of 20 tumor cell lines are reported. Three nonrandom chromosomal changes, namely, a loss of a chromosome #13, the presence of an i(6p), or a trisomy of 1q were observed. The potential importance of these chromosomal changes in tumor development is discussed, particularly the loss of a chromosome #13 or the gain of an i(6p). At least one of the three chromosomal changes was found in 75% of the tumor lines analyzed.

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Mesh：

Year:  1983        PMID： 6652613     DOI： 10.1016/0165-4608(83)90090-0

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  10 in total

Review 1.  Role of the retinoblastoma gene in the initiation and progression of human cancer.

Authors:  W F Benedict; H J Xu; S X Hu; R Takahashi
Journal:  J Clin Invest       Date:  1990-04       Impact factor: 14.808

2.  Asbestos-associated chromosomal changes in human mesothelial cells.

Authors:  J F Lechner; T Tokiwa; M LaVeck; W F Benedict; S Banks-Schlegel; H Yeager; A Banerjee; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

3.  Gene inactivation as a mechanism for the expression of recessive phenotypes.

Authors:  S G Grant; C E Campbell; C Duff; S L Toth; R G Worton
Journal:  Am J Hum Genet       Date:  1989-10       Impact factor: 11.025

4.  Chromosomes of metastatic retinoblastoma.

Authors:  H A Daly; E V Davison; A D Pearson; M M Reid; A W Craft
Journal:  Arch Dis Child       Date:  1987-04       Impact factor: 3.791

5.  Clinical implications of promoter hypermethylation in RASSF1A and MGMT in retinoblastoma.

Authors:  Kwong Wai Choy; Tom C Lee; Kin Fai Cheung; Dorothy S P Fan; Kwok Wai Lo; Katherine L Beaverson; David H Abramson; Dennis S C Lam; Christopher B O Yu; Chi Pui Pang
Journal:  Neoplasia       Date:  2005-03       Impact factor: 5.715

6.  A detailed analysis of chromosomal changes in heritable and non-heritable retinoblastoma.

Authors:  J Squire; B L Gallie; R A Phillips
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

7.  Identification of a single chromosome in the normal human genome essential for suppression of hamster cell transformation.

Authors:  A Stoler; N Bouck
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

8.  The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.

Authors:  Q J Hu; N Dyson; E Harlow
Journal:  EMBO J       Date:  1990-04       Impact factor: 11.598

9.  Structural alterations of the RB1 gene in human soft tissue tumours.

Authors:  M R Stratton; S Williams; C Fisher; A Ball; G Westbury; B A Gusterson; C D Fletcher; J C Knight; Y K Fung; B R Reeves
Journal:  Br J Cancer       Date:  1989-08       Impact factor: 7.640

10.  High level amplification of N-MYC is not associated with adverse histology or outcome in primary retinoblastoma tumours.

Authors:  D M Lillington; L K Goff; J E Kingston; Z Onadim; E Price; P Domizio; B D Young
Journal:  Br J Cancer       Date:  2002-09-23       Impact factor: 7.640
  10 in total

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