Literature DB >> 6652378

Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones.

R A North, J T Williams.   

Abstract

Opiates act on mu-receptors to increase the potassium conductance of rat locus coeruleus neurones. Opiates also depress the rate of rise and peak amplitude of calcium action potentials in these cells. The action of opiates on calcium action potentials was prevented by two procedures which blocked the opiate-induced potassium current, intracellular caesium and extracellular barium. This indicates that the opiate reduction in calcium entry is secondary to an increased potassium current.

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Year:  1983        PMID： 6652378      PMCID： PMC2045013          DOI： 10.1111/j.1476-5381.1983.tb10023.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  11 in total

1.  Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

Authors:  A W Mudge; S E Leeman; G D Fischbach
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

Review 2.  In vitro models in the study of structure-activity relationships of narcotic analgesics.

Authors:  H W Kosterlitz; A A Waterfield
Journal:  Annu Rev Pharmacol       Date:  1975       Impact factor: 13.820

3.  Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo.

Authors:  T L Yaksh; T M Jessell; R Gamse; A W Mudge; S E Leeman
Journal:  Nature       Date:  1980-07-10       Impact factor: 49.962

4.  Noradrenergic terminal excitability: effects of opioids.

Authors:  S Nakamura; J M Tepper; S J Young; N Ling; P M Groves
Journal:  Neurosci Lett       Date:  1982-05-17       Impact factor: 3.046

5.  Electrophysiological properties of neurons contained in the locus coeruleus and mesencephalic nucleus of the trigeminal nerve in vitro.

Authors:  G Henderson; C M Pepper; S A Shefner
Journal:  Exp Brain Res       Date:  1982       Impact factor: 1.972

6.  Enkephalin opens potassium channels on mammalian central neurones.

Authors:  J T Williams; T M Egan; R A North
Journal:  Nature       Date:  1982-09-02       Impact factor: 49.962

7.  Enkephalin reduces calcium action potentials in Rohon-Beard neurons in vivo.

Authors:  J L Bixby; N C Spitzer
Journal:  J Neurosci       Date:  1983-05       Impact factor: 6.167

8.  Opioid peptides decrease calcium-dependent action potential duration of mouse dorsal root ganglion neurons in cell culture.

Authors:  M A Werz; R L Macdonald
Journal:  Brain Res       Date:  1982-05-06       Impact factor: 3.252

9.  Influence of morphine and naloxone on the release of noradrenaline from rat brain cortex slices.

Authors:  H Montel; K Starke; F Weber
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

10.  Mature spinal ganglion cells are not sensitive to opiate receptor mediated actions.

Authors:  J Williams; W Zieglgänsberger
Journal:  Neurosci Lett       Date:  1981-01-20       Impact factor: 3.046
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  25 in total

1.  T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray.

Authors:  Cheongdahm Park; Jong-Hyun Kim; Bo-Eun Yoon; Eui-Ju Choi; C Justin Lee; Hee-Sup Shin
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-03       Impact factor: 11.205

Review 2.  Convergent regulation of locus coeruleus activity as an adaptive response to stress.

Authors:  Rita J Valentino; Elisabeth Van Bockstaele
Journal:  Eur J Pharmacol       Date:  2008-01-19       Impact factor: 4.432

3.  On the potassium conductance increased by opioids in rat locus coeruleus neurones.

Authors:  R A North; J T Williams
Journal:  J Physiol       Date:  1985-07       Impact factor: 5.182

4.  Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones.

Authors:  R L Macdonald; M A Werz
Journal:  J Physiol       Date:  1986-08       Impact factor: 5.182

5.  [The effect of central nervous modulation on the quality of epidural blockade.].

Authors:  H Ponhold
Journal:  Schmerz       Date:  1988-06       Impact factor: 1.107

6.  Activation of mu- and delta-opioid receptors present on the same nerve terminals depresses transmitter release in the mouse hypogastric ganglion.

Authors:  H Rogers; G Henderson
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

7.  Effect of opiates on transmitter release from visualized hypogastric boutons innervating the rat pelvic ganglia.

Authors:  D A Warren; N A Lavidis
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

Review 8.  Stimulatory effects of opioids on transmitter release and possible cellular mechanisms: overview and original results.

Authors:  Y Sarne; A Fields; O Keren; M Gafni
Journal:  Neurochem Res       Date:  1996-11       Impact factor: 3.996

9.  Calcium channel involvement in magnetic field inhibition of morphine-induced analgesia.

Authors:  M Kavaliers; K P Ossenkopp
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-09       Impact factor: 3.000

10.  Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

Authors:  R A Gross; R L Macdonald
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205
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