Literature DB >> 6652376

The actions of Paf-acether (platelet-activating factor) on guinea-pig isolated heart preparations.

J Benveniste, C Boullet, C Brink, C Labat.   

Abstract

Paf-acether (platelet-activating factor) is a phospholipid capable of stimulating platelets to release their granular contents and cause platelet aggregation. When Paf-acether was administered to isolated heart preparations from normal guinea-pigs there was a significant concentration-dependent reduction in coronary flow and contractile force. The high concentration of Paf-acether was equally effective in reducing these cardiac parameters in the presence of atropine. The non-acetylated Paf-acether analogue, 2-lyso Paf-acether, the enantiomer, and a closely related phospholipid 1, alpha-lysophosphatidylcholine palmitoyl, did not affect coronary flow and contractile force, indicating the specificity of Paf-acether. These data demonstrate a potent effect of Paf-acether on cardiac function. Whether or not these effects are direct or mediated through generation of endogenous mediators remains to be established.

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Year:  1983        PMID： 6652376      PMCID： PMC2044971          DOI： 10.1111/j.1476-5381.1983.tb11052.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  7 in total

1.  Aggregation of rabbit platelets by platelet-activating factor is independent of the release reaction and the arachidonate pathway and inhibited by membrane-active drugs.

Authors:  J P Cazenave; J Benveniste; J F Mustard
Journal:  Lab Invest       Date:  1979-09       Impact factor: 5.662

2.  Activation of rabbit platelets by platelet-activating factor derived from IgE-sensitized basophils. Characteristics of the aggregation and its dissociation from secretion.

Authors:  P M Henson
Journal:  J Clin Invest       Date:  1977-08       Impact factor: 14.808

3.  The role of platelet-activating factor in platelet aggregation.

Authors:  M Chignard; J P Le Couedic; M Tence; B B Vargaftig; J Benveniste
Journal:  Nature       Date:  1979-06-28       Impact factor: 49.962

4.  Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs.

Authors:  P Bessin; J Bonnet; D Apffel; C Soulard; L Desgroux; I Pelas; J Benveniste
Journal:  Eur J Pharmacol       Date:  1983-01-21       Impact factor: 4.432

5.  [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine].

Authors:  J Benveniste; M Tencé; P Varenne; J Bidault; C Boullet; J Polonsky
Journal:  C R Seances Acad Sci D       Date:  1979-11-26

6.  Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

Authors:  C A Demopoulos; R N Pinckard; D J Hanahan
Journal:  J Biol Chem       Date:  1979-10-10       Impact factor: 5.157

7.  Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor.

Authors:  J Benveniste; P M Henson; C G Cochrane
Journal:  J Exp Med       Date:  1972-12-01       Impact factor: 14.307
  7 in total
  27 in total

1.  Reversible or irreversible modification of [3H]PAF binding on rabbit platelet membranes differentiates various PAF receptor antagonists.

Authors:  M T Domingo; F Piro; C Broquet; E Auclair; P E Chabrier; P Braquet
Journal:  Lipids       Date:  1992-08       Impact factor: 1.880

2.  Electrophysiological and arrhythmogenic effects of platelet activating factor during normal perfusion, myocardial ischaemia and reperfusion in the guinea-pig.

Authors:  N A Flores; D J Sheridan
Journal:  Br J Pharmacol       Date:  1990-11       Impact factor: 8.739

3.  Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4.

Authors:  P J Piper; A G Stewart
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739

Review 4.  Cardiovascular effects of platelet-activating factor.

Authors:  R E Goldstein; G Z Feuerstein; L M Bradley; J J Stambouly; F R Laurindo; N J Davenport
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

5.  Role of platelet-activating factor in the reperfusion injury of rabbit ischemic heart.

Authors:  G Montrucchio; G Alloatti; F Mariano; R de Paulis; A Comino; G Emanuelli; G Camussi
Journal:  Am J Pathol       Date:  1990-07       Impact factor: 4.307

6.  Molecular and cellular actions of platelet-activating factor in rat heart cells.

Authors:  C V Massey; T A Kohout; S T Gaa; W J Lederer; T B Rogers
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

7.  Effects of platelet-activating factor on single potassium channel currents in guinea pig ventricular myocytes.

Authors:  G M Wahler; D E Coyle; N Sperelakis
Journal:  Mol Cell Biochem       Date:  1990-03-05       Impact factor: 3.396

8.  Interaction of the Paf antagonist WEB 2086 and its hetrazepine analogues with human platelets and endothelial cells.

Authors:  R Korth; M Hirafuji; C L Keraly; D Delautier; J Bidault; J Benveniste
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

9.  Role of thromboxane A2, leukotriene C4 and histamine in the antigen-induced vasoconstriction in perfused, sensitized guinea-pig kidney.

Authors:  N A Abdullah; E S Assem
Journal:  Agents Actions       Date:  1989-04

10.  Mechanisms of pulmonary vasoconstriction and bronchoconstriction produced by PAF in the guinea-pig: role of platelets and cyclo-oxygenase metabolites.

Authors:  L Argiolas; F Fabi; P del Basso
Journal:  Br J Pharmacol       Date:  1995-01       Impact factor: 8.739
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