| Literature DB >> 66517 |
M R Moore, P A Meredith, A Goldberg.
Abstract
Blood-lead concentrations were measured retrospectively in the blood contained on cards used for testing for phenylketonuria in the first two weeks of life. Cards which belonged to 80 of a group of 77 children with mental retardation of unknown aetiology and 77 controls were identified. Of 77 usable cards, 41 were from mentally retarded children and 36 were from controls; 24 mental-retardation/control pairs were found. There was a highly significant trend towards higher blood-lead concentrations in the mentally retarded children. Water-lead concentrations in the maternal home during pregnancy correlated with blood-lead concentrations in the mentally retarded children. These results reinforce the probable association between lead exposure during pregnancy and the development of mental retardation of otherwise unknown aetiology.Entities:
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Year: 1977 PMID： 66517 DOI： 10.1016/s0140-6736(77)92165-1
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321