Chiasma-derived genetic lengths and recombination fractions: a reciprocal translocation 46,XY,t(1;22) (q32;q13).

The chiasma distribution in a human male carrier of a balanced reciprocal translocation 46,XY,t(1;22) (q32;q13) has been compared with data from six controls. The translocation carrier shows a raised chiasma frequency and altered chiasma distribution in chromosome 1, particularly in the region adjacent to the breakpoint. These changes are expected to distort the recombination pattern, implying that caution should be taken when trying to incorporate linkage data from translocation families into the normal genetic map.