Literature DB >> 6648616

Accumulation of vancomycin after intraventricular infusions.

J C Arroyo, E A Quindlen.   

Abstract

A 50-year-old man with an infected intracerebral hematoma was treated with daily intraventricular infusions containing 10 mg of vancomycin (half the dose suggested by others). A vancomycin level in the ventricular CSF of 606 micrograms/ml after nine days of therapy indicates a potential for accumulation of this drug in patients with extensive brain damage.

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Year:  1983        PMID： 6648616     DOI： 10.1097/00007611-198312000-00023

Source DB:  PubMed          Journal:  South Med J        ISSN： 0038-4348            Impact factor:   0.954


  7 in total

Review 1.  Pharmacokinetics and administration regimens of vancomycin in neonates, infants and children.

Authors:  K A Rodvold; J A Everett; R D Pryka; D M Kraus
Journal:  Clin Pharmacokinet       Date:  1997-07       Impact factor: 6.447

Review 2.  Systematic review of efficacy, pharmacokinetics, and administration of intraventricular vancomycin in adults.

Authors:  Karen Ng; Vincent H Mabasa; Ivy Chow; Mary H H Ensom
Journal:  Neurocrit Care       Date:  2014-02       Impact factor: 3.210

3.  A Systematic Review of Studies Reporting Antibiotic Pharmacokinetic Data in the Cerebrospinal Fluid of Critically Ill Patients with Uninflamed Meninges.

Authors:  Nilesh Kumta; Jason A Roberts; Jeffrey Lipman; Wai Tat Wong; Gavin M Joynt; Menino Osbert Cotta
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.191

4.  Bactericidal activity of vancomycin in cerebrospinal fluid.

Authors:  M Nagl; C Neher; J Hager; B Pfausler; E Schmutzhard; F Allerberger
Journal:  Antimicrob Agents Chemother       Date:  1999-08       Impact factor: 5.191

5.  Staphylococcus aureus ventriculitis treated with single-dose intraventricular vancomycin or daptomycin (LY146032): bacterial and antibiotic kinetics in hydrocephalic rabbits.

Authors:  C S Haworth; M W Sobieski; W M Scheld; T S Park
Journal:  Antimicrob Agents Chemother       Date:  1990-02       Impact factor: 5.191

Review 6.  Clinical pharmacokinetics of vancomycin.

Authors:  G R Matzke; G G Zhanel; D R Guay
Journal:  Clin Pharmacokinet       Date:  1986 Jul-Aug       Impact factor: 6.447

Review 7.  Central nervous system infections: a critical care approach.

Authors:  W C Ziai; R G Geocadin
Journal:  Curr Neurol Neurosci Rep       Date:  2001-11       Impact factor: 6.030
  7 in total

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