Literature DB >> 6644814

Preliminary crystallographic study of the complex between the Fab fragment of a monoclonal anti-lysozyme antibody and its antigen.

R A Mariuzza, D L Janković, G Boulot, A G Amit, P Saludjian, A Le Guern, J C Mazié, R J Poljak.   

Abstract

Preliminary crystallographic data are given for the complex between the Fab fragment of a monoclonal anti-lysozyme antibody and its antigen. This crystalline complex was found by screening a number of Fab-lysozyme complexes prepared from monoclonal anti-lysozyme antibodies produced by hybrids of BALB/c immune spleen cells with a non-secreting mouse hybrid myeloma line. The complex crystallizes in the monoclinic space group P21 with a = 55.5 (+/- 0.1) A, b = 143.5 (+/- 0.3) A, c = 49.1 (+/- 0.1) A, beta = 120 degrees 20' (+/- 10'). X-ray photographs show reflections extending to a resolution of 2.7 A. The crystals are suitable for high-resolution X-ray diffraction studies.

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Year:  1983        PMID： 6644814     DOI： 10.1016/s0022-2836(83)80206-x

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  6 in total

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2.  A protease-dependent mechanism for initiating T-dependent B cell responses to large particulate antigens.

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4.  CD5 maintains tolerance in anergic B cells.

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5.  A strategy to identify linker-based modules for the allosteric regulation of antibody-antigen binding affinities of different scFvs.

Authors:  Sarah-Jane Kellmann; Stefan Dübel; Holger Thie
Journal:  MAbs       Date:  2017-04       Impact factor: 5.857

6.  Visualization of the genesis and fate of isotype-switched B cells during a primary immune response.

Authors:  Kathryn A Pape; Valerie Kouskoff; David Nemazee; H Lucy Tang; Jason G Cyster; Lina E Tze; Keli L Hippen; Timothy W Behrens; Marc K Jenkins
Journal:  J Exp Med       Date:  2003-06-09       Impact factor: 14.307
  6 in total

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