| Literature DB >> 6644751 |
J M McCall, J W Aiken, C G Chidester, D W DuCharme, M G Wendling.
Abstract
Di- and triaminopyrimidine 3-oxides (e.g., 2,4-diamino-6-piperidinylpyrimidine 3-oxide and 2,4-diamino-6-(diallylamino)triazine 3-oxide) react with sources of sulfur trioxide, such as sulfur trioxide trimethylamine or chlorosulfuryl chloride, to yield the corresponding heterocyclic O-sulfates. These sulfates are inner salts with unusual physical properties. The structure of the O-sulfate of 2,4-diamino-6-piperidinylpyrimidine 3-oxide was confirmed by X-ray. These O-sulfates are hypotensives. They apparently act by direct vasodilation.Entities:
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Year: 1983 PMID： 6644751 DOI： 10.1021/jm00366a030
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446