Literature DB >> 6642679

Lung tissue concentrations of cefoperazone.

K Wartenberg, J Tonak, W Knapp.   

Abstract

The following lung tissue concentrations of cefoperazone were found in 20 patients after a 2 g single dose: 45.3-113.3 mg/kg after one hour and 20.5-68.1 mg/kg after two hours. The respective serum levels were measured in parallel determinations for comparison purposes. All determinations were carried out by means of high pressure liquid chromatography. The results suggest that cefoperazone has a rapid and sustained concentration ability in the lung tissue. The drug is therefore suitable for perioperative prophylaxis in lung surgery.

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Year:  1983        PMID： 6642679     DOI： 10.1007/BF01641263

Source DB:  PubMed          Journal:  Infection        ISSN： 0300-8126            Impact factor:   3.553


  2 in total

1.  Cefoperazone: absorption, excretion, distribution, and metabolism.

Authors:  K Shimizu
Journal:  Clin Ther       Date:  1980       Impact factor: 3.393

2.  Determination of cephalosporins in biological material by reversed-phase liquid column chromatography.

Authors:  A M Brisson; J B Fourtillan
Journal:  J Chromatogr       Date:  1981-05-08
  2 in total
  3 in total

Review 1.  Cefoperazone prevents the inactivation of alpha(1)-antitrypsin by activated neutrophils.

Authors:  F Dallegri; P Dapino; N Arduino; M Bertolotto; L Ottonello
Journal:  Antimicrob Agents Chemother       Date:  1999-09       Impact factor: 5.191

2.  Pharmacokinetic studies of CP-74,667, a new quinolone, in laboratory animals.

Authors:  D Girard; T D Gootz; P R McGuirk
Journal:  Antimicrob Agents Chemother       Date:  1992-08       Impact factor: 5.191

3.  In vivo efficacy of trovafloxacin (CP-99,219), a new quinolone with extended activities against gram-positive pathogens, Streptococcus pneumoniae, and Bacteroides fragilis.

Authors:  A E Girard; D Girard; T D Gootz; J A Faiella; C R Cimochowski
Journal:  Antimicrob Agents Chemother       Date:  1995-10       Impact factor: 5.191
  3 in total

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