Literature DB >> 6642133

Enhancement by potassium bromate of renal tumorigenesis initiated by N-ethyl-N-hydroxyethylnitrosamine in F-344 rats.

Y Kurokawa, M Takahashi, T Kokubo, Y Ohno, Y Hayashi.   

Abstract

The effect of potassium bromate, a food additive, was examined in male F-344 rats based on two-stage renal carcinogenesis with N-ethyl-N-hydroxyethylnitrosamine (EHEN) as an initiator. Average numbers of dysplastic foci and renal cell tumors were significantly increased in rats given potassium bromate after initiation with EHEN. It was concluded that potassium bromate has an enhancing effect on renal tumorigenesis.

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Year:  1983        PMID： 6642133

Source DB:  PubMed          Journal:  Gan        ISSN： 0016-450X


  4 in total

Review 1.  Toxicity and carcinogenicity of potassium bromate--a new renal carcinogen.

Authors:  Y Kurokawa; A Maekawa; M Takahashi; Y Hayashi
Journal:  Environ Health Perspect       Date:  1990-07       Impact factor: 9.031

2.  Possible application to medium-term organ bioassays for renal carcinogenesis modifiers in rats treated with N-ethyl-N-hydroxyethylnitrosamine and unilateral nephrectomy.

Authors:  Y Hiasa; N Konishi; S Nakaoka; M Nakamura; S Nishii; Y Kitahori; M Ohshima
Journal:  Jpn J Cancer Res       Date:  1991-12

3.  Long-term in vivo carcinogenicity tests of potassium bromate, sodium hypochlorite, and sodium chlorite conducted in Japan.

Authors:  Y Kurokawa; S Takayama; Y Konishi; Y Hiasa; S Asahina; M Takahashi; A Maekawa; Y Hayashi
Journal:  Environ Health Perspect       Date:  1986-11       Impact factor: 9.031

4.  Promoting effects of potassium dibasic phosphate on early-stage renal carcinogenesis in unilaterally nephrectomized rats treated with N-ethyl-N-hydroxyethylnitrosamine.

Authors:  Y Hiasa; N Konishi; S Nakaoka; T Nakamura; K Nishii; M Ohshima
Journal:  Jpn J Cancer Res       Date:  1992-07
  4 in total

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