Literature DB >> 6641946

Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum.

I A Vorobjev, D B Zorov.   

Abstract

Diazepam (70-150 micrograms/ml) significantly inhibits oxygen consumption by pig kidney embryo cells and causes the cellular ATP level to fall. The maximum inhibitory effect develops after 1.5-2.5 h of diazepam treatment. In isolated mitochondria diazepam inhibits respiration in state 2 and 3u with glutamate and in state 3u with succinate. Ethylrhodamine staining and electron microscopic study reveal fragmentation of mitochondria in living cells.

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Year:  1983        PMID： 6641946     DOI： 10.1016/0014-5793(83)80842-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


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