Literature DB >> 6641939

Uncoupling protein in human brown adipose tissue mitochondria. Isolation and detection by specific antiserum.

M E Lean, W P James.   

Abstract

A protein of Mr 32 000 has been isolated from human infant brown adipose tissue mitochondria following the procedure used to purify the uncoupling protein from rat brown adipose tissue mitochondria. A specific antiserum has been raised against the human 32 kDa protein, and used to detect it by probing mitochondrial proteins separated by SDS-PAGE. The protein is present in large amounts in brown adipose tissue but is undetectable in human liver, heart or white adipose tissue. It has strong immunological cross-reactivity with rat brown adipose tissue uncoupling protein.

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Year:  1983        PMID： 6641939     DOI： 10.1016/0014-5793(83)80826-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue.

Authors:  Suriyan Ponnusamy; Quynh T Tran; Innocence Harvey; Heather S Smallwood; Thirumagal Thiyagarajan; Souvik Banerjee; Daniel L Johnson; James T Dalton; Ryan D Sullivan; Duane D Miller; Dave Bridges; Ramesh Narayanan
Journal:  FASEB J       Date:  2016-10-12       Impact factor: 5.191

Review 2.  Brown adipose tissue: development, metabolism and beyond.

Authors:  Tim J Schulz; Yu-Hua Tseng
Journal:  Biochem J       Date:  2013-07-15       Impact factor: 3.857

3.  Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Sudden occurrence of uncoupling protein mRNA during embryogenesis and its disappearance after birth.

Authors:  L Casteilla; O Champigny; F Bouillaud; J Robelin; D Ricquier
Journal:  Biochem J       Date:  1989-02-01       Impact factor: 3.857

Review 4.  The role of skeletal-muscle-based thermogenic mechanisms in vertebrate endothermy.

Authors:  Leslie A Rowland; Naresh C Bal; Muthu Periasamy
Journal:  Biol Rev Camb Philos Soc       Date:  2014-11-25

5.  Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs.

Authors:  B Meister; G Fried; T Hökfelt; H C Hemmings; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

6.  Brown Adipose Tissue: A Short Historical Perspective.

Authors:  Paul Trayhurn
Journal:  Methods Mol Biol       Date:  2022

7.  Convertible adipose tissue in mice.

Authors:  D Loncar
Journal:  Cell Tissue Res       Date:  1991-10       Impact factor: 5.249
  7 in total

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