Literature DB >> 6640518

Growth in agar and tumor formation in immunologically incompetent mice as criteria for keratinocyte transformation.

G Cowley, B Gusterson, J Knight.   

Abstract

Established cell lines from 8 human squamous cell carcinomas (SCC) together with normal human keratinocytes, have been investigated for their ability to grow in soft agar and as xenografts when injected as a single cell suspension into immunologically incompetent mice. One of 8 SCC lines formed colonies with efficiencies greater than 1% in soft agar, and only 2 formed progressively growing tumors when injected into animals. It is concluded that these 2 criteria are not reliable markers of malignant transformation in squamous epithelia unless cytological criteria are also applied.

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Year:  1983        PMID： 6640518     DOI： 10.1016/0304-3835(83)90088-5

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  3 in total

1.  Human breast epithelium transplanted into nude mice. Proliferation and milk protein production in response to pregnancy.

Authors:  B A Gusterson; J Williams; H Bunnage; M J O'Hare; J D Dubois
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1984

2.  Increased EGF receptors on human squamous carcinoma cell lines.

Authors:  G P Cowley; J A Smith; B A Gusterson
Journal:  Br J Cancer       Date:  1986-02       Impact factor: 7.640

Review 3.  Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.

Authors:  Shengming Zhu; Jiangang Wang; Lucas Zellmer; Ningzhi Xu; Mei Liu; Yun Hu; Hong Ma; Fei Deng; Wenxiu Yang; Dezhong Joshua Liao
Journal:  J Cancer       Date:  2022-07-04       Impact factor: 4.478
  3 in total

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