The carcinogenic effect of butylated hydroxyanisole on the stratified epithelium of the stomach in rat versus pig.

Butylated hydroxyanisole (BHA) was given to pregnant SPF pigs (Danish Landrace) in doses of 0, 50, 200 and 400 mg/kg body wt per day for 110 days. BHA was mixed in the diet (pelleted). Hyperkeratotic and parakeratotic proliferative changes of the stratified epithelium of the stomach were found at various degree in both control and dosed pigs. Papillomas were not found and no changes of the glandular part of the stomach were observed.