Literature DB >> 6639889

Effect of alpha thalassaemia on the rheology of homozygous sickle cell disease.

B E Serjeant, K P Mason, M W Kenny, J Stuart, D R Higgs, D J Weatherall, R J Hayes, G R Serjeant.   

Abstract

A study of rheological determinants (plasma viscosity, whole-blood viscosity, and erythrocyte deformability) was made in 24 matched pairs of patients with homozygous sickle cell disease, with and without homozygous alpha-thalassaemia 2. Patients with coexisting alpha-thalassaemia showed a significant increase in erythrocyte deformability measured as filtration of washed erythrocytes through 5 micron diameter pores and also as viscosity of whole blood at high shear rate (230s-1) and standard haematocrit (0.45). This rheological advantage may explain the beneficial effect of alpha-thalassaemia 2 on haematological parameters and clinical events in homozygous sickle cell disease.

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Year:  1983        PMID： 6639889     DOI： 10.1111/j.1365-2141.1983.tb02163.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  9 in total

1.  Cardiorespiratory responses during three repeated incremental exercise tests in sickle cell trait carriers.

Authors:  Laurent Marlin; Philippe Connes; Sophie Antoine-Jonville; Julien Tripette; Mona Montout-Hedreville; Alain Sanouiller; Maryse Etienne-Julan; Olivier Hue
Journal:  Eur J Appl Physiol       Date:  2007-10-02       Impact factor: 3.078

2.  Alpha thalassemia changes erythrocyte heterogeneity in sickle cell disease.

Authors:  C T Noguchi; G J Dover; G P Rodgers; G R Serjeant; S E Antonarakis; N P Anagnou; D R Higgs; D J Weatherall; A N Schechter
Journal:  J Clin Invest       Date:  1985-05       Impact factor: 14.808

3.  Blood rheology and proliferative retinopathy in homozygous sickle cell disease.

Authors:  B E Serjeant; K P Mason; R W Acheson; G H Maude; J Stuart; G R Serjeant
Journal:  Br J Ophthalmol       Date:  1986-07       Impact factor: 4.638

4.  Alpha-thalassaemia and response to hydroxyurea in sickle cell anaemia.

Authors:  Deepika S Darbari; Mehdi Nouraie; James G Taylor; Carlo Brugnara; Oswaldo Castro; Samir K Ballas
Journal:  Eur J Haematol       Date:  2014-01-30       Impact factor: 2.997

5.  Blood rheology and proliferative retinopathy in sickle cell-haemoglobin C disease.

Authors:  B E Serjeant; K P Mason; P I Condon; R J Hayes; M W Kenny; J Stuart; G R Serjeant
Journal:  Br J Ophthalmol       Date:  1984-05       Impact factor: 4.638

Review 6.  Genetic, laboratory and clinical risk factors in the development of overt ischemic stroke in children with sickle cell disease.

Authors:  André Rolim Belisário; Célia Maria Silva; Cibele Velloso-Rodrigues; Marcos Borato Viana
Journal:  Hematol Transfus Cell Ther       Date:  2017-11-26

7.  The pleiotropic effects of α-thalassemia on HbSS and HbSC sickle cell disease: Reduced erythrocyte cation co-transport activity, serum erythropoietin, and transfusion burden, do not translate into increased survival.

Authors:  John N Brewin; Amina Nardo-Marino; Sara Stuart-Smith; Sara El Hoss; Anke Hanneman; John Strouboulis; Stephan Menzel; John S Gibson; David C Rees
Journal:  Am J Hematol       Date:  2022-07-18       Impact factor: 13.265

8.  Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia.

Authors:  Sharon E Cox; Julie Makani; Charles R Newton; Andrew M Prentice; Fenella J Kirkham
Journal:  ISRN Hematol       Date:  2013-04-03

9.  Haptoglobin, alpha-thalassaemia and glucose-6-phosphate dehydrogenase polymorphisms and risk of abnormal transcranial Doppler among patients with sickle cell anaemia in Tanzania.

Authors:  Sharon E Cox; Julie Makani; Deogratias Soka; Veline S L'Esperence; Edward Kija; Paula Dominguez-Salas; Charles R J Newton; Anthony A Birch; Andrew M Prentice; Fenella J Kirkham
Journal:  Br J Haematol       Date:  2014-02-21       Impact factor: 6.998
  9 in total

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