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Literature DB >> 6639005

Diethylcarbamazine citrate, an antifilarial drug, stimulates human granulocyte adherence.

Abstract

Incubation with diethylcarbamazine citrate caused significant augmentation of human neutrophil and eosinophil adherence to tissue culture plastic. This effect was dose dependent and cell dependent, with eosinophils showing greater sensitivity and a greater adhesive response to the drug than did neutrophils. Eosinophils preincubated with diethylcarbamazine citrate demonstrated decreased adhesive responses to other adherence-augmenting stimuli. Use of Fc-treated plastic augmented diethylcarbamazine citrate-stimulated neutrophil (but not eosinophil) adherence. Direct stimulation of host effector cell adherence may explain, in part, the therapeutic action of diethylcarbamazine citrate in vivo.

Entities: Chemical Species

Mesh：

Substances：
Diethylcarbamazine

Year: 1983 PMID： 6639005 PMCID： PMC185347 DOI： 10.1128/AAC.24.3.453

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

1. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes.

Authors: R D Nelson; P G Quie; R L Simmons
Journal: J Immunol Date: 1975-12 Impact factor: 5.422

2. Observation with the ultropak microscope on microf lariae of Litomosoide carinii cirucloating in the liver of a cotton-rat, before anf after the adminstration of hetrazan.

Authors: A E TAYLOR
Journal: Trans R Soc Trop Med Hyg Date: 1960-09 Impact factor: 2.184

3. Onchocercal dermatitis: ultrastructural studies of microfilariae and host tissues, before and after treatment with diethylcarbamazine (Hetrazan).

Authors: D W Gibson; D H Connor; H L Brown; H Fuglsang; J Anderson; B O Duke; A A Buck
Journal: Am J Trop Med Hyg Date: 1976-01 Impact factor: 2.345

4. A new method for the purification of human eosinophils and neutrophils, and a comparison of the ability of these cells to damage schistosomula of Schistosoma mansoni.

Authors: M A Vadas; J R David; A Butterworth; N T Pisani; T A Siongok
Journal: J Immunol Date: 1979-04 Impact factor: 5.422

1. Acute tropical pulmonary eosinophilia. Characterization of the lower respiratory tract inflammation and its response to therapy.

Authors: P Pinkston; V K Vijayan; T B Nutman; W N Rom; K M O'Donnell; M J Cornelius; V Kumaraswami; V J Ferrans; T Takemura; G Yenokida
Journal: J Clin Invest Date: 1987-07 Impact factor: 14.808

2. Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.

Authors: Helen F McGarry; Leigh D Plant; Mark J Taylor
Journal: Filaria J Date: 2005-06-02

2 in total

Diethylcarbamazine citrate, an antifilarial drug, stimulates human granulocyte adherence.

1. Chemotaxis under agarose: a new and simple method for measuring chemotaxis and spontaneous migration of human polymorphonuclear leukocytes and monocytes.

2. Observation with the ultropak microscope on microf lariae of Litomosoide carinii cirucloating in the liver of a cotton-rat, before anf after the adminstration of hetrazan.

3. Onchocercal dermatitis: ultrastructural studies of microfilariae and host tissues, before and after treatment with diethylcarbamazine (Hetrazan).

4. A new method for the purification of human eosinophils and neutrophils, and a comparison of the ability of these cells to damage schistosomula of Schistosoma mansoni.

5. Ultrastructural changes in Litomosoides carinii microfilariae in gerbils treated with diethylcarbamazine.

6. Inhibition of leukotriene biosynthesis in mastocytoma cells by diethylcarbamazine.

7. Immunoglobulin and complement receptors on human eosinophils and their role in cellular adherence to schistosomules.

8. Role of secretory events in modulating human neutrophil chemotaxis.

9. Neutrophil adhesiveness during prostacyclin and heparin hemodialysis.

10. The influence of chemotactic factors on neutrophil adhesiveness.

1. Acute tropical pulmonary eosinophilia. Characterization of the lower respiratory tract inflammation and its response to therapy.

2. Diethylcarbamazine activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.