Literature DB >> 6638991

Antimicrobial activity and other in vitro properties of cefoperazone A, the principal metabolite of cefoperazone sodium.

R N Jones, A L Barry.   

Abstract

Cefoperazone A, the principal metabolite of cefoperazone, was found to have an antimicrobial activity ranging from slightly below to 16-fold less than that of the parent drug. Like cefoperazone, the metabolite is bactericidal, penetrates well into bacterial cells, and has moderate beta-lactamase stability, some strains of members of the family Enterobacteriaceae produce an inoculum effect on the metabolite activity.

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Year:  1983        PMID： 6638991      PMCID： PMC185156          DOI： 10.1128/AAC.24.2.293

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  8 in total

1.  Cefoperazone: absorption, excretion, distribution, and metabolism.

Authors:  K Shimizu
Journal:  Clin Ther       Date:  1980       Impact factor: 3.393

2.  Antimicrobial activity of desacetylcefotaxime alone and in combination with cefotaxime: evidence of synergy.

Authors:  R N Jones; A L Barry; C Thornsberry
Journal:  Rev Infect Dis       Date:  1982 Sep-Oct

3.  Cefotetan, a new cephamycin: comparison of in vitro antimicrobial activity with other cephems, beta-lactamase stability, and preliminary recommendations for disk diffusion testing.

Authors:  L W Ayers; R N Jones; A L Barry; C Thornsberry; P C Fuchs; T L Gavan; E H Gerlach; H M Sommers
Journal:  Antimicrob Agents Chemother       Date:  1982-11       Impact factor: 5.191

Review 4.  Cefoperazone: a review of its antimicrobial spectrum, beta-lactamase stability, enzyme inhibition, and other in vitro characteristics.

Authors:  R N Jones; A L Barry
Journal:  Rev Infect Dis       Date:  1983 Mar-Apr

5.  Biliary excretion of cephalosporins in rats: influence of molecular weight.

Authors:  W E Wright; V D Line
Journal:  Antimicrob Agents Chemother       Date:  1980-05       Impact factor: 5.191

6.  Clinical experience with cefoperazone in biliary tract infections.

Authors:  K Mashimo
Journal:  Drugs       Date:  1981       Impact factor: 9.546

Review 7.  Cefoperazone: A review of its in vitro antimicrobial activity, pharmacological properties and therapeutic efficacy.

Authors:  R N Brogden; A Carmine; R C Heel; P A Morley; T M Speight; G S Avery
Journal:  Drugs       Date:  1981-12       Impact factor: 9.546

8.  Cefoperazone concentrations in bile and gall bladder wall after intravenous administration.

Authors:  T Nakamura; I Hashimoto; Y Sawada; J Mikami; E Bekki; S Hirasawa; H Abe; Y Watanabe
Journal:  Antimicrob Agents Chemother       Date:  1980-12       Impact factor: 5.191
  8 in total
  1 in total

1.  Susceptibilities of 45 clinical isolates of Proteus penneri.

Authors:  M Fuksa; S Krajden; A Lee
Journal:  Antimicrob Agents Chemother       Date:  1984-09       Impact factor: 5.191
  1 in total

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