Literature DB >> 6637621

Lactate production in a pure red muscle in absence of anoxia: mechanisms and significance.

R J Connett, T E Gayeski, C R Honig.   

Abstract

Neither lactate accumulation in nor lactate release from muscle tissue can be used as evidence of anoxic tissue. We propose that the principal function of the lactate accumulation in tissue is to buffer cytosolic NADH levels and promote AEROBIC ATP production. This aerobic function of lactate metabolism should increase efficiency and extend the range of muscle performance.

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Year:  1983        PMID: 6637621     DOI: 10.1007/978-1-4684-7790-0_28

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  4 in total

1.  Lactic acid: New roles in a new millennium.

Authors:  L B Gladden
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-16       Impact factor: 11.205

2.  The relationship between lactic acid and work load: a measure for endurance capacity or an indicator of carbohydrate deficiency?

Authors:  N Maassen; M W Busse
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1989

Review 3.  Lactate metabolism: historical context, prior misinterpretations, and current understanding.

Authors:  Brian S Ferguson; Matthew J Rogatzki; Matthew L Goodwin; Daniel A Kane; Zachary Rightmire; L Bruce Gladden
Journal:  Eur J Appl Physiol       Date:  2018-01-10       Impact factor: 3.078

Review 4.  Oxygen flux from capillary to mitochondria: integration of contemporary discoveries.

Authors:  David C Poole; Timothy I Musch; Trenton D Colburn
Journal:  Eur J Appl Physiol       Date:  2021-12-23       Impact factor: 3.078

  4 in total

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