| Literature DB >> 6637151 |
J Hirvonen, P Huttunen, K P Martimo, J Puurunen.
Abstract
The effect on rat gastric mucosa of ethanol and acetylsalicylic acid given at two doses singly or in combination were studied by administering the drugs into the stomach. 40% ethanol alone caused many ulcerations after 5 h, and the effect was even more marked with simultaneous administration of acetylsalicylic acid (ASA). 10% ethanol and 50 mg ASA/kg b. wt. were tolerated well. The mucosal lesions consisted of coagulation necrosis and hemorrhages, with a disappearance of histamine and serotonin from the mucosal mast cells in and around the lesion.Entities:
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Year: 1983 PMID： 6637151 DOI： 10.1007/BF02116198
Source DB: PubMed Journal: Z Rechtsmed ISSN： 0044-3433