Literature DB >> 6636112

HLA-B8/DR3 in sarcoidosis. Correlation to acute onset disease with arthritis.

E Hedfors, F Lindström.   

Abstract

HLA-A, B, C and DR typing was performed in 19 patients with sarcoidosis of acute onset. Besides bilateral hilar lymph node enlargement (BHL), ankle joint involvement was found in all and erythema nodosum in seven. HLA-B8 was present in 13 and HLA-DR3 in 17 of the 19 patients. The joint manifestations and the erythema nodosum subsided in all within three months. The BHL regressed completely in seventeen patients during a three year observation period. In two patients with an observation period of one year and less than six months, respectively, BHL were still visible. The strong association between the acute, prognostically beneficial manifestation of sarcoidosis and HLA-DR3 might partly be related to the presence of circulating immune complexes in acute sarcoidosis as well as to an immunogenetically determined handling of a postulated etiological antigen.

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Year:  1983        PMID： 6636112     DOI： 10.1111/j.1399-0039.1983.tb01192.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  18 in total

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Review 2.  Ankylosing spondylitis and sarcoidosis--coincidence or association? Case report and review of the literature.

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Review 3.  Genetics of sarcoidosis: candidate genes and genome scans.

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4.  Early prediction of sarcoidosis prognosis with HLA typing: a 5 year follow-up study.

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5.  Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients.

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6.  Bronchoalveolar lavage characteristics correlate with HLA tag SNPs in patients with Löfgren's syndrome and other sarcoidosis.

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7.  Sex-specific manifestations of Löfgren's syndrome.

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8.  Sarcoid arthritis: clinical characteristics, diagnostic aspects, and risk factors.

Authors:  H Visser; K Vos; E Zanelli; W Verduyn; G M Th Schreuder; I Speyer; F C Breedveld; J M W Hazes
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Authors:  Mary J Mattapallil; Phyllis B Silver; Joseph J Mattapallil; Reiko Horai; Zaruhi Karabekian; J Hugh McDowell; Chi-Chao Chan; Eddie A James; William W Kwok; H Nida Sen; Robert B Nussenblatt; Chella S David; Rachel R Caspi
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10.  Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101.

Authors:  Kyra Oswald-Richter; Hiroe Sato; Rana Hajizadeh; Bryan E Shepherd; John Sidney; Alessandro Sette; Lee S Newman; Wonder Puryear Drake
Journal:  J Clin Immunol       Date:  2009-06-18       Impact factor: 8.317
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