Literature DB >> 6634880

Loss of cholinergic neurons in the rat neocortex produces deficits in passive avoidance learning.

E Friedman, B Lerer, J Kuster.   

Abstract

Bilateral kainic acid lesions of the ventral globus pallidus produced a significant and selective cortical decrease in choline acetyltransferase activity in the rat brain. When lesioned and control subjects were compared on performance of a step-through passive avoidance task, lesioned rats showed a marked retention deficit 24 hr after the initial training trial. This experimentally-induced memory deficit associated with a cortical cholinergic neuronal loss resembles the deficits in senile dementia of the Alzheimer type and may provide a useful animal model for studying the disease.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6634880     DOI： 10.1016/0091-3057(83)90057-6

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  14 in total

1.  Alterations in neocortical expression of nicotinic acetylcholine receptor mRNAs following unilateral lesions of the rat nucleus basalis magnocellularis.

Authors:  I Miyai; S Ueno; S Yorifuji; H Fujimura; S Tarui
Journal:  J Neural Transm Gen Sect       Date:  1990

2.  Intracortical grafts of embryonic basal forebrain tissue restore low voltage fast activity in rats with basal forebrain lesions.

Authors:  C H Vanderwolf; A Fine; R K Cooley
Journal:  Exp Brain Res       Date:  1990       Impact factor: 1.972

3.  Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopaminergic and cholinergic receptors as evaluated by positron emission tomography in the Rhesus monkey.

Authors:  Y Tani; T Ishihara; T Kanai; T Ohno; J Andersson; A Lilja; G Antoni; K J Fasth; P Bjurling; G Westerberg
Journal:  J Neural Transm Gen Sect       Date:  1995

4.  Local cerebral glucose utilization in the autoimmune New Zealand black (NZB) mouse.

Authors:  A Wree; T Beck; G W Bielenberg; A Schleicher; K Zilles
Journal:  Histochemistry       Date:  1989

5.  Cholinergic ventral forebrain grafts into the neocortex improve passive avoidance memory in a rat model of Alzheimer disease.

Authors:  A Fine; S B Dunnett; A Björklund; S D Iversen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

6.  Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats.

Authors:  R J Mandel; L J Thal
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

7.  Transplantation of basal forebrain cells of foetal rats into the subarachnoid space: improvement of disturbance of passive avoidance memory due to injury of nucleus basalis magnocellularis.

Authors:  K Kyoshima; M Matsuda; J Handa
Journal:  Acta Neurochir (Wien)       Date:  1995       Impact factor: 2.216

8.  Cholinergic suppression: a postsynaptic mechanism of long-term associative learning.

Authors:  A D Morielli; E M Matera; M P Kovac; R G Shrum; K J McCormack; W J Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

9.  Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus Basalis of Meynert in rat.

Authors:  Zahra Rabiei; Mahmoud Rafieian-Kopaei; Esfandiar Heidarian; Elham Saghaei; Shiva Mokhtari
Journal:  Neurochem Res       Date:  2013-12-31       Impact factor: 3.996

Review 10.  Modeling Alzheimer's disease with non-transgenic rat models.

Authors:  Laurent Lecanu; Vassilios Papadopoulos
Journal:  Alzheimers Res Ther       Date:  2013-05-01       Impact factor: 6.982
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.