Literature DB >> 6634053

Drug prevention of blood-aqueous barrier disruption.

N J van Haeringen, E Glasius, J A Oosterhuis, J L van Delft.   

Abstract

In order to evaluate the anti-inflammatory effect of non-steroidal compounds on the eye, we tested them in rabbits using the inhibitory effect on paracentesis-induced disruption of the blood-aqueous barrier. Protein and--after intravenous-injection--fluorescein were determined in punctates of aqueous humor. Indomethacin, flurbiprofen and diclofenac in a 0.01% solution showed a marked inhibitory effect, which lasted for 24 h. Addition of polysorbate to eye drugs diminished the inhibitory effect.

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Year:  1983        PMID: 6634053     DOI: 10.1159/000265255

Source DB:  PubMed          Journal:  Ophthalmic Res        ISSN: 0030-3747            Impact factor:   2.892


  5 in total

Review 1.  The incidence, pathogenesis and treatment of cystoid macular edema following cataract surgery.

Authors:  A J Flach
Journal:  Trans Am Ophthalmol Soc       Date:  1998

2.  The effect of flurbiprofen 0.03% eye drops on the blood aqueous barrier in extracapsular cataract extraction with IOL implantation.

Authors:  M Diestelhorst; F Aspacher; W Konen; G K Krieglstein
Journal:  Int Ophthalmol       Date:  1991-03       Impact factor: 2.031

3.  Effect of indomethacin on aqueous PGE2 levels in rabbits following ocular trauma.

Authors:  C Skorpik; P Paroussis; M Grasl; H D Gnad
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1987       Impact factor: 3.117

4.  Dexamethasone and indomethacin attenuate cryopexy. Induced breakdown of the blood-retinal barrier.

Authors:  J H Stahl; D B Miller; B P Conway; P A Campochiaro
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1987       Impact factor: 3.117

Review 5.  Ocular diclofenac. A review of its pharmacology and clinical use in cataract surgery, and potential in other inflammatory ocular conditions.

Authors:  K L Goa; P Chrisp
Journal:  Drugs Aging       Date:  1992 Nov-Dec       Impact factor: 3.923

  5 in total

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