Studies on the effect of tobacco smoke on the biotransformation of vasoactive substances in the isolated perfused rabbit lung. II. Angiotensin I conversion.

Cigarette smoke administration was previously found to have a pronounced inhibitory effect on metabolism of nicotine and benzo[a]pyrene in the isolated perfused rabbit lung. These observations suggest the possibility of tobacco smoke inhibition of biotransformations associated with non-ventilatory pulmonary functions such as the biotransformation of endogenous vasoactive substances. However, the present study provides no evidence of an effect of smoke on the conversion of angiotensin I to angiotensin II in the isolated perfused rabbit lung.