Literature DB >> 6633672

The deamination of noradrenaline and 5-hydroxytryptamine by rat brain and heart monoamine oxidase and their inhibition by cimoxatone, toloxatone and MD 770222.

M Strolin Benedetti, T Boucher, C J Fowler.   

Abstract

In both rat brain and heart, noradrenaline and 5-hydroxytryptamine are metabolised predominantly by monoamine oxidase-A. The Km values for 14C-noradrenaline in the rat brain and heart are 290 microM and 300 microM, respectively, whereas for 14C-5-hydroxytryptamine the values are 180 microM and 140 microM, respectively. In the rat brain, mixed substrate experiments suggested that 14C-noradrenaline and 14C-5-hydroxytryptamine are metabolised at the same active centre. Both substrates are inhibited with similar Ki values by the reversible inhibitors cimoxatone, toloxatone and MD 770222.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6633672     DOI： 10.1007/BF00512469

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  32 in total

1.  Substrate- and inhibitor-related characteristics of human platelet monoamine oxidase.

Authors:  C H Donnelly; D L Murphy
Journal:  Biochem Pharmacol       Date:  1977-05-01       Impact factor: 5.858

2.  Some puzzling pharmacological effects of monoamine oxidase inhibitors.

Authors:  J Knoll; K Magyar
Journal:  Adv Biochem Psychopharmacol       Date:  1972

3.  Some factors influencing the metabolism of benzylamine by type A and B monoamine oxidase in rat heart and liver.

Authors:  D Parkinson; G A Lyles; B J Browne; B A Callingham
Journal:  J Pharm Pharmacol       Date:  1980-12       Impact factor: 3.765

4.  Studies on the subcellular localization of monoamine oxidase types A and B and its importance for the deamination of dopamine in the rat brain.

Authors:  S Urwyler; J P von Wartburg
Journal:  Biochem Pharmacol       Date:  1980-11-15       Impact factor: 5.858

5.  Serotonin oxidation by type B MAO of rat brain.

Authors:  C Mitra; S R Guha
Journal:  Biochem Pharmacol       Date:  1980-05-01       Impact factor: 5.858

6.  Substrate selectivity of type A and type B monoamine oxidase in rat brain.

Authors:  H Kinemuchi; Y Wakui; K Kamijo
Journal:  J Neurochem       Date:  1980-07       Impact factor: 5.372

7.  Subcellular localization of types A and B monoamine oxidase in rat brain.

Authors:  A K Student; D J Edwards
Journal:  Biochem Pharmacol       Date:  1977-12-15       Impact factor: 5.858

8.  Monoamine oxidase type A: differences in selectivity towards l-norepinephrine compared to serotonin.

Authors:  N A Garrick; D L Murphy
Journal:  Biochem Pharmacol       Date:  1982-12-15       Impact factor: 5.858

9.  The metabolism of dopamine by both forms of monoamine oxidase in the rat brain and its inhibition by cimoxatone.

Authors:  C J Fowler; M S Benedetti
Journal:  J Neurochem       Date:  1983-06       Impact factor: 5.372

10.  Substrate specificity of monoamine oxidase in pig liver mitochondria.

Authors:  B Ekstedt
Journal:  Med Biol       Date:  1979-08
View more
  6 in total

1.  Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice.

Authors:  Marco Bortolato; Kevin Chen; Sean C Godar; Gao Chen; Weihua Wu; Igor Rebrin; Mollee R Farrell; Anna L Scott; Cara L Wellman; Jean C Shih
Journal:  Neuropsychopharmacology       Date:  2011-08-10       Impact factor: 7.853

2.  Propranolol inhibits nonexocytotic noradrenaline release in myocardial ischemia.

Authors:  G Richardt; U Lumpp; M Haass; A Schömig
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990 Jan-Feb       Impact factor: 3.000

3.  Myocardial H2O2 production in the unanaesthetized rat. Influence of fasting, myocardial load and inhibition of superoxide dismutase and monoamine oxidase.

Authors:  I Kerckaert; F Roels
Journal:  Basic Res Cardiol       Date:  1986 Jan-Feb       Impact factor: 17.165

4.  Relation between brain monoamine oxidase (MAO) activity and the firing rate of locus coeruleus neurons.

Authors:  L Oreland; G Engberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-07       Impact factor: 3.000

5.  The activity of the neuronal and extraneuronal catecholamine-metabolizing enzymes of the perfused rat heart.

Authors:  M Grohmann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-08       Impact factor: 3.000

6.  Rhesus monkey cerebrospinal fluid amine metabolite changes following treatment with the reversible monoamine oxidase type-A inhibitor cimoxatone.

Authors:  N A Garrick; T Seppala; M Linnoila; D L Murphy
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.