Literature DB >> 6633300

Cytotoxin production by Clostridium sordellii strains.

S Nakamura, N Tanabe, K Yamakawa, S Nishida.   

Abstract

A total of 55 strains of Clostridium sordellii, 21 lethal toxin-positive and 34 lethal toxin-negative, were tested for cytotoxin production in brain heart infusion medium supplemented with 0.2% Na2HPO4 (m-BHI) and cooked-meat-glucose (CMG) medium using baby hamster kidney (BHK-21/WI-2) cells as indicator cells. The m-BHI medium was preferred to CMG medium and 24 hr of incubation was sufficient for cytotoxin production. Nineteen of the 21 toxigenic strains were also cytotoxigenic, and the strength of the cytotoxigenicity was approximately parallel with that of the lethal toxigenicity. Clostridium difficile antitoxin neutralized C. sordellii cytotoxin and also C. sordellii antitoxin neutralized C. difficile cytotoxin.

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Year:  1983        PMID： 6633300     DOI： 10.1111/j.1348-0421.1983.tb00611.x

Source DB:  PubMed          Journal:  Microbiol Immunol        ISSN： 0385-5600            Impact factor:   1.955


  7 in total

Review 1.  Toxigenic clostridia.

Authors:  C L Hatheway
Journal:  Clin Microbiol Rev       Date:  1990-01       Impact factor: 26.132

Review 2.  Clostridium difficile: its disease and toxins.

Authors:  D M Lyerly; H C Krivan; T D Wilkins
Journal:  Clin Microbiol Rev       Date:  1988-01       Impact factor: 26.132

3.  Non-toxigenic Clostridium sordellii: clinical and microbiological features of a case of cholangitis-associated bacteremia.

Authors:  Seth T Walk; Ruchika Jain; Itishree Trivedi; Sylvia Grossman; Duane W Newton; Tennille Thelen; Yibai Hao; J Glenn Songer; Glen P Carter; Dena Lyras; Vincent B Young; David M Aronoff
Journal:  Anaerobe       Date:  2011-06-25       Impact factor: 3.331

4.  Purification and characterization of Clostridium sordellii hemorrhagic toxin and cross-reactivity with Clostridium difficile toxin A (enterotoxin).

Authors:  R D Martinez; T D Wilkins
Journal:  Infect Immun       Date:  1988-05       Impact factor: 3.441

5.  Lethal toxin is a critical determinant of rapid mortality in rodent models of Clostridium sordellii endometritis.

Authors:  Yibai Hao; Tennille Senn; Judy S Opp; Vincent B Young; Teri Thiele; Geetha Srinivas; Steven K Huang; David M Aronoff
Journal:  Anaerobe       Date:  2009-06-13       Impact factor: 3.331

6.  Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions.

Authors:  Xingxing Li; Liuqing He; Jianhua Luo; Yangling Zheng; Yao Zhou; Danyang Li; Yuanyuan Zhang; Zhenrui Pan; Yanyan Li; Liang Tao
Journal:  Nat Commun       Date:  2022-07-26       Impact factor: 17.694

7.  Purification and characterization of Clostridium sordellii lethal toxin and cross-reactivity with Clostridium difficile cytotoxin.

Authors:  M R Popoff
Journal:  Infect Immun       Date:  1987-01       Impact factor: 3.441
  7 in total

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