Preliminary study on fixed rabies virus strain "Roma". I: Adaptation on BHK21/S13 cells.

In this study the attempts to adapt Roma fixed rabies virus to BHK21/S13 cells and human diploid fibroblasts, for a better characterization of the virus, are reported. BHK21 cells were infected with the virus and maintained in culture for more than 100 passages. A persistently infected culture by rabies virus was obtained. Attempts to propagate virus in human diploid fibroblasts were unsuccessful.