| Literature DB >> 6633162 |
M J Welch, M R Kilbourn, C J Mathias, M A Mintun, M E Raichle.
Abstract
Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 +/- 1.6 is obtained two hours after administration of the 18F-spiroperidol. When 18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.Entities:
Mesh：
Substances：
Year: 1983 PMID： 6633162 DOI： 10.1016/0024-3205(83)90725-7
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037