Literature DB >> 6632723

Lung cancer patients' autoimmune responses to Thomsen-Friedenreich (T) antigen: diagnostic utility.

W A Fry, G F Springer, P R Desai.   

Abstract

The usefulness of T antigen in the diagnosis of lung cancer (LCA), including early, was assessed by determining the in vitro delayed type hypersensitivity response to T(DTHR-T), and by measuring with a solid phase immunofluorescent assay the serum anti-T IgM response. Sensitivity of DTHR-T was 89% for 73 patients with LCA including 8/9 with Stage T1N0M0 disease, overall specificity was 95% for 212 healthy persons and those with non-CA disease. The humoral immune assay detected 31/35 (89%) LCA patients including 4/5 Stage T1N0M0 patients. Overall specificity was greater than 90% among 116 persons without CA.

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Year:  1983        PMID: 6632723     DOI: 10.1007/BF01496727

Source DB:  PubMed          Journal:  Klin Wochenschr        ISSN: 0023-2173


  13 in total

1.  Blood group MN antigens and precursors in normal and malignant human breast glandular tissue.

Authors:  G F Springer; P R Desai; I Banatwala
Journal:  J Natl Cancer Inst       Date:  1975-02       Impact factor: 13.506

2.  The T antigen of guinea-pig and human red cells.

Authors:  F M BURNET; S G ANDERSON
Journal:  Aust J Exp Biol Med Sci       Date:  1947-09

Review 3.  Human carcinoma-associated precursor antigens of the blood group MN system and the host's immune responses to them.

Authors:  G F Springer; P R Desai; M S Murthy; H Tegtmeyer; E F Scanlon
Journal:  Prog Allergy       Date:  1979

4.  Proposed molecular basis of murine tumor cell-hepatocyte interaction.

Authors:  G F Springer; R Cheingsong-Popov; V Schirrmacher; P R Desai; H Tegtmeyer
Journal:  J Biol Chem       Date:  1983-05-10       Impact factor: 5.157

5.  Detection of lung- and breast carcinoma by quantitating serum anti-T IgM levels with a sensitive, solid-phase immunoassay.

Authors:  G F Springer; P R Desai
Journal:  Naturwissenschaften       Date:  1982-07

6.  Blood group-like activity released by human mammary carcinoma cells in culture.

Authors:  J H Anglin; M P Lerner; R E Nordquist
Journal:  Nature       Date:  1977-09-15       Impact factor: 49.962

7.  Blood group MN precursors as human breast carcinoma-associated antigens and "naturally" occurring human cytotoxins against them.

Authors:  G F Springer; P R Desai; E F Scanlon
Journal:  Cancer       Date:  1976-01       Impact factor: 6.860

8.  Decreased levels of circulating lytic anti-T in the serum of patients with metastatic gastrointestinal cancer: a correlation with disease burden.

Authors:  J Bray; G D MacLean; F J Dusel; T A McPherson
Journal:  Clin Exp Immunol       Date:  1982-01       Impact factor: 4.330

9.  Delayed-type cutaneous hypersensitivity to Thomsen-Friedenreich (T) antigen in patients with pancreatic cancer.

Authors:  R L Goodale; G F Springer; J G Shearen; P R Desai; H Tegtmeyer
Journal:  J Surg Res       Date:  1983-10       Impact factor: 2.192

10.  Heterophile antibodies, immunoglobulin levels, and the evaluation on anti-T activity in cancer patients and controls.

Authors:  G H Vos; P Brain
Journal:  S Afr Med J       Date:  1981-07-25
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  1 in total

Review 1.  Cancer vaccines and carbohydrate epitopes.

Authors:  Jamie Heimburg-Molinaro; Michelle Lum; Geraldine Vijay; Miten Jain; Adel Almogren; Kate Rittenhouse-Olson
Journal:  Vaccine       Date:  2011-10-01       Impact factor: 3.641

  1 in total

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