Literature DB >> 6631687

Simple reliable method for chronic cannulation of the jugular vein for pharmacokinetic studies in rats.

S K Bakar, S Niazi.   

Abstract

A simple method for the preparation and implantation of silicone cannulas into the rat jugular vein is described. The implanted cannula can be used to administer drugs and collect blood samples at intervals of less than or equal to 1 min without causing stress to the animal. If necessary, the animals can be exsanuinated within a few minutes using this cannula. With proper maintenance, the cannula is patent for weeks and could be used for repeated and crossover studies.

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Year:  1983        PMID： 6631687     DOI： 10.1002/jps.2600720915

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  6 in total

1.  Lipid association increases the potency against primary medulloblastoma cells and systemic exposure of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in rats.

Authors:  C Bethune; A Blum; J R Geyer; J R Silber; R J Ho
Journal:  Pharm Res       Date:  1999-06       Impact factor: 4.200

2.  High-pressure liquid chromatographic analysis of BMY-28142 in plasma and urine.

Authors:  R H Barbhaiya; S T Forgue; W C Shyu; E A Papp; K A Pittman
Journal:  Antimicrob Agents Chemother       Date:  1987-01       Impact factor: 5.191

3.  Preclinical pharmacokinetics and stability of isophosphoramide mustard.

Authors:  J J Zheng; K K Chan; F Muggia
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

4.  Influence of permanent cannulation of the jugular vein on pharmacokinetics of amoxycillin and antipyrine in the rat.

Authors:  F Torres-Molina; J C Aristorena; C Garcia-Carbonell; L Granero; J Chesa-Jiménez; J Pla-Delfina; J E Peris-Ribera
Journal:  Pharm Res       Date:  1992-12       Impact factor: 4.200

5.  Pharmacokinetics of the novel cephalosporin cefepime (BMY-28142) in rats and monkeys.

Authors:  S T Forgue; W C Shyu; C R Gleason; K A Pittman; R H Barbhaiya
Journal:  Antimicrob Agents Chemother       Date:  1987-05       Impact factor: 5.191

6.  New coronary retroinfusion technique in the Rat infarct model: transjugular cardiac vein catheterization.

Authors:  Zheyong Huang; Yunli Shen; Hongmin Zhu; Jianfeng Xu; Yanan Song; Xinying Hu; Zhang Shuning; Xiangdong Yang; Aijun Sun; Juying Qian; Junbo Ge
Journal:  Exp Anim       Date:  2013
  6 in total

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