Literature DB >> 6631441

Effects of 4-aminopyridine in patients with multiple sclerosis.

R E Jones, J R Heron, D H Foster, R S Snelgar, R J Mason.   

Abstract

4-Aminopyridine (4-AP) was administered to two groups of patients with multiple sclerosis (MS). The first group consisted of 5 patients with labile visual symptoms, 2 of whom had arcuate scotomata. 4-AP improved visual performance of most patients in this group and reduced the size of scotomata. The second group consisted of 5 patients with the spinal form of MS who were in a stable state; in this group 4-AP had little effect clinically or on tests of visual function.

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Year:  1983        PMID: 6631441     DOI: 10.1016/0022-510x(83)90145-4

Source DB:  PubMed          Journal:  J Neurol Sci        ISSN: 0022-510X            Impact factor:   3.181


  20 in total

Review 1.  Potassium channel blockers as an effective treatment to restore impulse conduction in injured axons.

Authors:  Riyi Shi; Wenjing Sun
Journal:  Neurosci Bull       Date:  2011-02       Impact factor: 5.203

2.  Visual changes mediated by beer in retrobulbar neuritis--an investigative case report.

Authors:  S L Alvarez; N A Jacobs; I J Murray
Journal:  Br J Ophthalmol       Date:  1986-02       Impact factor: 4.638

Review 3.  [4-Aminopyridine (Fampridine). A new attempt for the symptomatic treatment of multiple sclerosis].

Authors:  L Husseini; V I Leussink; B C Kieseier; H-P Hartung
Journal:  Nervenarzt       Date:  2010-02       Impact factor: 1.214

4.  Treatment of walking impairment in multiple sclerosis with dalfampridine.

Authors:  Andrew R Blight
Journal:  Ther Adv Neurol Disord       Date:  2011-03       Impact factor: 6.570

5.  Extended-release dalfampridine in the management of multiple-sclerosis-related walking impairment.

Authors:  Carrie Hersh; Alex Rae-Grant
Journal:  Ther Adv Neurol Disord       Date:  2012-07       Impact factor: 6.570

Review 6.  4-Aminopyridine for symptomatic treatment of multiple sclerosis: a systematic review.

Authors:  Henrik Boye Jensen; Mads Ravnborg; Ulrik Dalgas; Egon Stenager
Journal:  Ther Adv Neurol Disord       Date:  2014-03       Impact factor: 6.570

7.  Effect of 4-aminopyridine on vision in multiple sclerosis patients with optic neuropathy.

Authors:  Lindsay Horton; Amy Conger; Darrel Conger; Gina Remington; Teresa Frohman; Elliot Frohman; Benjamin Greenberg
Journal:  Neurology       Date:  2013-04-24       Impact factor: 9.910

8.  The effects of anticonvulsants on 4-aminopyridine-induced bursting: in vitro studies on rat peripheral nerve and dorsal roots.

Authors:  G Lees
Journal:  Br J Pharmacol       Date:  1996-02       Impact factor: 8.739

9.  Delayed depolarization and slow sodium currents in cutaneous afferents.

Authors:  O Honmou; D A Utzschneider; M A Rizzo; C M Bowe; S G Waxman; J D Kocsis
Journal:  J Neurophysiol       Date:  1994-05       Impact factor: 2.714

Review 10.  Enhancing neural transmission in multiple sclerosis (4-aminopyridine therapy).

Authors:  Andrew D Goodman; Robert Thompson Stone
Journal:  Neurotherapeutics       Date:  2013-01       Impact factor: 7.620

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