Literature DB >> 6630196

Beta-hydroxyaspartic acid in vitamin K-dependent proteins.

P Fernlund, J Stenflo.   

Abstract

A method for the quantitation of beta-hydroxyaspartic acid in proteins is described. After hydrolysis in 6 M HCl, the beta-hydroxyaspartic acid released is quantitated on an automatic amino acid analyzer employing a pH 2.0 eluting buffer and postcolumn reaction with o-phthalaldehyde for detection. The sensitivity is about 0.01 nmol. Among vitamin K-dependent proteins, factor IX, factor X, protein C, and protein Z each contain about one residue of beta-hydroxyaspartic acid whereas protein S contains two or three residues. Prothrombin lacks beta-hydroxyaspartic acid as do a number of non-vitamin K-dependent proteins also analyzed.

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Year:  1983        PMID： 6630196

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  35 in total

1.  Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains.

Authors:  C T Przysiecki; J E Staggers; H G Ramjit; D G Musson; A M Stern; C D Bennett; P A Friedman
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

2.  Group D prothrombin activators from snake venom are structural homologues of mammalian blood coagulation factor Xa.

Authors:  Veena S Rao; Jeremiah S Joseph; R Manjunatha Kini
Journal:  Biochem J       Date:  2003-02-01       Impact factor: 3.857

3.  Modeling zymogen protein C.

Authors:  L Perera; C Foley; T A Darden; D Stafford; T Mather; C T Esmon; L G Pedersen
Journal:  Biophys J       Date:  2000-12       Impact factor: 4.033

4.  Primary structure of bovine vitamin K-dependent protein S.

Authors:  B Dahlbäck; A Lundwall; J Stenflo
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

5.  Vitamin K-dependent protein S in Leydig cells of human testis.

Authors:  J Malm; X H He; A Bjartell; L Shen; P A Abrahamsson; B Dahlbäck
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

6.  Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.

Authors:  G J Arlaud; A C Willis; J Gagnon
Journal:  Biochem J       Date:  1987-02-01       Impact factor: 3.857

7.  Suppression of hemostatic system activation by oral anticoagulants in the blood of patients with thrombotic diatheses.

Authors:  E M Conway; K A Bauer; S Barzegar; R D Rosenberg
Journal:  J Clin Invest       Date:  1987-12       Impact factor: 14.808

8.  Aspartyl beta-hydroxylase: in vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX.

Authors:  R S Gronke; W J VanDusen; V M Garsky; J W Jacobs; M K Sardana; A M Stern; P A Friedman
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

9.  [The clinical importance of protein C and S deficiency for surgical patients].

Authors:  H Rabl; H Fruhwirth
Journal:  Langenbecks Arch Chir       Date:  1992

10.  Interactions among the epidermal growth factor-like modules of thrombospondin-1.

Authors:  Yuanyuan Liu; Douglas S Annis; Deane F Mosher
Journal:  J Biol Chem       Date:  2009-06-16       Impact factor: 5.157
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