Literature DB >> 6630183

Bradykinin reverses the effect of opiates in the gut by enhancing acetylcholine release.

D J Goldstein, T G Ropchak, H R Keiser, G J Atta, A Argiolas, J J Pisano.   

Abstract

Four naturally occurring peptides of the kinin family, bradykinin, lysylbradykinin, methionyllysylbradykinin, and polisteskinin reverse the inhibitory effect of morphine, metenkephalin, and epinephrine on the electrically stimulated guinea pig ileum longitudinal muscle myenteric plexus preparation. Bradykinin, the most potent kinin, enhances the release of acetylcholine in the gut, and its reversal of the opiate inhibitory effect is blocked by the anticholinergic drug, hyoscine.

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Year:  1983        PMID： 6630183

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  4 in total

1.  Actions of bradykinin on electrical and synaptic behavior of neurones in the myenteric plexus of guinea-pig small intestine.

Authors:  Hong-Zhen Hu; Sumei Liu; Na Gao; Yun Xia; Randa Mostafa; Jun Ren; Dimiter H Zafirov; Jackie D Wood
Journal:  Br J Pharmacol       Date:  2003-04       Impact factor: 8.739

2.  Bradykinin-induced contraction of guinea pig lung in vitro.

Authors:  E Lach; A Trifilieff; M Mousli; Y Landry; J P Gies
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-08       Impact factor: 3.000

3.  Bradykinin stimulation of phosphoinositide hydrolysis in guinea-pig ileum longitudinal muscle.

Authors:  R W Ransom; C B Goodman; G S Young
Journal:  Br J Pharmacol       Date:  1992-04       Impact factor: 8.739

4.  The competitive antagonistic effect of compounds from Mandevilla velutina on kinin-induced contractions of rat uterus and guinea-pig ileum in vitro.

Authors:  J B Calixto; M G Pizzolatti; R A Yunes
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739
  4 in total

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