Literature DB >> 6630073

Northienamycin and 8-epi-thienamycin, new carbapenems from Streptomyces cattleya.

K E Wilson, A J Kempf, J M Liesch, B H Arison.   

Abstract

Two new carbapenem antibiotics, northienamycin and 8-epi-thienamycin have been isolated from culture broth of Streptomyces cattleya grown under conditions for thienamycin production. The isolation, structure elucidation and in vitro antibacterial spectra of the new carbapenems are reported. In addition, comparison of the in vitro potency of the corresponding formamidine derivatives to that of MK787 is presented.

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Year:  1983        PMID： 6630073     DOI： 10.7164/antibiotics.36.1109

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Methylations in complex carbapenem biosynthesis are catalyzed by a single cobalamin-dependent radical S-adenosylmethionine enzyme.

Authors:  Erica K Sinner; Michael S Lichstrahl; Rongfeng Li; Daniel R Marous; Craig A Townsend
Journal:  Chem Commun (Camb)       Date:  2019-12-10       Impact factor: 6.222

2.  ThnL, a B12-dependent radical S-adenosylmethionine enzyme, catalyzes thioether bond formation in carbapenem biosynthesis.

Authors:  Erica K Sinner; Rongfeng Li; Daniel R Marous; Craig A Townsend
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-15       Impact factor: 12.779

3.  Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics.

Authors:  Micah J Bodner; Ryan M Phelan; Michael F Freeman; Rongfeng Li; Craig A Townsend
Journal:  J Am Chem Soc       Date:  2010-01-13       Impact factor: 15.419

4.  C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation.

Authors:  Nichole K Stewart; Marta Toth; Maha A Alqurafi; Weirui Chai; Thu Q Nguyen; Pojun Quan; Mijoon Lee; John D Buynak; Clyde A Smith; Sergei B Vakulenko
Journal:  mBio       Date:  2022-04-14       Impact factor: 7.786
  4 in total

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