Literature DB >> 6629668

d,1-alpha-Tocopheryl acetate (vitamin E): a long term toxicity and carcinogenicity study in rats.

G H Wheldon, A Bhatt, P Keller, H Hummler.   

Abstract

Rats were fed vitamin E at various dietary concentrations providing dosages of up to 2000 mg/kg bodyweight/day for 104 weeks. Vitamin K supplementation suppressed the induced hypoprothrombinaemia. Growth rate and survival were unaltered by treatment, and, apart from a trend towards fewer mammary tumours in females, the tumour profile was unaffected. Changes in serum liver enzyme activity and in the appearance of the hepatic macrophages suggested a limited hepatic response to vitamin E overload.

Entities:  

Mesh：

Substances：

Year:  1983        PMID： 6629668

Source DB:  PubMed          Journal:  Int J Vitam Nutr Res        ISSN： 0300-9831            Impact factor:   1.784


  9 in total

1.  Assessment of oral toxicity and safety of pentamethylchromanol (PMCol), a potential chemopreventative agent, in rats and dogs.

Authors:  Matthew Lindeblad; Izet M Kapetanovic; Kasim K Kabirov; Carol J Detrisac; Nancy Dinger; Irina Mankovskaya; Alexander Zakharov; Alexander V Lyubimov
Journal:  Toxicology       Date:  2010-04-27       Impact factor: 4.221

Review 2.  Complexity of vitamin E metabolism.

Authors:  Lisa Schmölz; Marc Birringer; Stefan Lorkowski; Maria Wallert
Journal:  World J Biol Chem       Date:  2016-02-26

3.  Deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrates sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion.

Authors:  Sherry M Farley; Scott W Leonard; Jan F Stevens; Maret G Traber
Journal:  Mol Nutr Food Res       Date:  2014-07-14       Impact factor: 5.914

Review 4.  Antioxidant vitamin supplements: update of their potential benefits and possible risks.

Authors:  S R Maxwell
Journal:  Drug Saf       Date:  1999-10       Impact factor: 5.606

Review 5.  How 'safe' are antioxidant vitamins?

Authors:  H S Garewal; A T Diplock
Journal:  Drug Saf       Date:  1995-07       Impact factor: 5.606

6.  [Reducing lipid peroxidation of stored frozen trout fillet by supplementing feed with vitamin E].

Authors:  H Gessl; P P Hoppe; I Elmadfa
Journal:  Z Ernahrungswiss       Date:  1995-09

Review 7.  The role of vitamin E in normal and damaged skin.

Authors:  F Nachbar; H C Korting
Journal:  J Mol Med (Berl)       Date:  1995-01       Impact factor: 4.599

8.  Organ-dependent modifying effects of caffeine, and two naturally occurring antioxidants alpha-tocopherol and n-tritriacontane-16,18-dione, on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary and colonic carcinogenesis in female F344 rats.

Authors:  A Hagiwara; P Boonyaphiphat; H Tanaka; M Kawabe; S Tamano; H Kaneko; M Matsui; M Hirose; N Ito; T Shirai
Journal:  Jpn J Cancer Res       Date:  1999-04

Review 9.  The effects of α-tocopherol on bone: a double-edged sword?

Authors:  Kok-Yong Chin; Soelaiman Ima-Nirwana
Journal:  Nutrients       Date:  2014-04-10       Impact factor: 5.717
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.