| Literature DB >> 6628564 |
N Wedel, P Toselli, C Pothoulakis, B Faris, P Oliver, C Franzblau, T LaMont.
Abstract
The mechanism by which Clostridium difficile toxin B causes cells in culture to round was investigated. Cultured human lung fibroblasts and rabbit aortic smooth muscle cells were treated with partially purified or purified toxin B and monitored by light and transmission electron microscopy (TEM). Both preparations caused progressive cell rounding which correlated with disorganization of actin-containing myofilament bundles. Thin myofilaments became fragmented and finally disappeared (after 24 h) and dense bodies became more prominent, while all other organelles appeared unaffected.Entities:
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Year: 1983 PMID： 6628564 DOI： 10.1016/0014-4827(83)90163-5
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905