Literature DB >> 66283

A human alloantiserum precipitates Ia-like molecules from chronic lymphocytic leukemia cells.

S Nilsson, B D Schwartz, M Waxdal, E Green, S E Cullen, D L Mann.   

Abstract

Alloantigens specific for human B lymphocytes can be identified with selected antisera. These antigens have similarities to murine Ia antigens in that they are found on human B lymphocytes and are controlled by genes linked to genes controlling HLA. Chronic lymphocytic leukemia cells bearing B cell antigens were labeled with 3H leucine and the membrane components reacting with the B cell antisera isolated by immunoprecipitation. These membrane components had m.w. of 33,000 and 24,000 daltons similar to the murine Ia antigens. The results complete the homology of murine Ia and human B cell alloantigens.

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Year:  1977        PMID： 66283

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  2 in total

1.  HLA-D associated alloantisera react with molecules similar to Ia antigens.

Authors:  M J Giphart; J F Kaufman; A Fuks; D Albrechtsen; B G Solheim; J W Bruning; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1977-08       Impact factor: 11.205

2.  Poor mixed lymphocyte reaction stimulatory capacity of leukemic B cells of chronic lymphocytic leukemia patients despite the presence of Ia antigens.

Authors:  J P Halper; S M Fu; A B Gottlieb; R J Winchester; H G Kunkel
Journal:  J Clin Invest       Date:  1979-11       Impact factor: 14.808
  2 in total

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