| Literature DB >> 6627242 |
I C Shaw, M I Graham, A E McLean.
Abstract
Chloroacetaldehyde has been shown to be a urinary metabolite of cyclophosphamide in the rat. It was identified in the urine of rats given a mixture of [ring C-4, 14C]-cyclophosphamide and [chloroethyl-3H]-cyclophosphamide as its 2,4-dinitrophenyl-hydrazone derivative by its 3H label and by its co-chromatography with chemically synthesised chloroacetaldehyde. The reaction of chloroacetaldehyde with another urinary metabolite of cyclophosphamide is discussed and a nornitrogen mustard adduct postulated. The toxicity of chloroacetaldehyde is also discussed particularly in relation to the urinary bladder.Entities:
Mesh：
Substances：
Year: 1983 PMID： 6627242 DOI： 10.1016/s0305-7372(83)80003-6
Source DB: PubMed Journal: Cancer Treat Rev ISSN： 0305-7372 Impact factor: 12.111