Effects of peroxisome proliferators on fatty acid-binding protein in rat liver.

The relationship between hepatic fatty acid-binding protein and peroxisomal beta-oxidation was studied. Rats were fed a diet containing p-chlorophenoxyisobutyric acid (clofibric acid), 2,2'-(decamethylenedithio)-diethanol (tiadenol), di-(2-ethylhexyl)-phthalate (DEHP), di-(2-ethylhexyl)-adipate (DEHA) and acetylsalicylic acid. On the administration of these peroxisome proliferators, both [1-14C]oleic acid-binding capacity and content of fatty acid-binding protein were increased, in association with an increase in peroxisomal beta-oxidation activity. The order of the increase in binding capacity and content of fatty acid-binding protein was tiadenol greater than DEHP greater than or equal to clofibric acid greater than DEHA = acetylsalicylic acid. The order of the increase in peroxisomal beta-oxidation activity in liver was tiadenol greater than clofibric acid greater than or equal to DEHP greater than DEHA = acetylsalicylic acid. Linear regression analysis between the binding capacity or content of fatty acid-binding protein and peroxisomal beta-oxidation activity was highly significant.