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Literature DB >> 6626423

The effect of a 5-HT antagonist, ketanserin, on blood pressure, the renin-angiotensin system and sympathoadrenal function in normal man.

C Zoccali, J R Zabludowski, C G Isles, G D Murray, G C Inglis, J I Robertson, R Fraser, S G Ball.

Abstract

The role of endogenous 5-hydroxytryptamine (5-HT) in the control of blood pressure, the renin-angiotensin system and sympatho-adrenal function was investigated in normal man. Ketanserin (a specific 5-HT2 antagonist) administered intravenously caused a small decrease in blood pressure in salt-depleted recumbent subjects. A more marked postural fall in pressure occurred in both sodium-depleted and repleted normal subjects. Plasma active renin concentration and angiotensin II increased after administration of ketanserin, but plasma aldosterone, cortisol and noradrenaline were unchanged. 5-HT may be important in the control of blood pressure in man and specific 5-HT2 receptor antagonists could be a useful new class of antihypertensive agents.

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Year: 1983 PMID： 6626423 PMCID： PMC1427997 DOI： 10.1111/j.1365-2125.1983.tb02166.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

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3. Estimation of angiotensin II concentration in human plasma by radioimmunoassay. Some applications to physiological and clinical states.

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8. Efficacy of antihypertensive drugs.

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