Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Neural 16S acetylcholinesterase is solubilized by heparin.

Literature DB >> 6626175

Neural 16S acetylcholinesterase is solubilized by heparin.

Abstract

The effect of heparin, a sulphated glycosaminoglycan, on the solubilization of rat sciatic-nerve acetylcholinesterase (acetylcholine acetylhydrolase; AChE; EC 3.1.1.7) was studied. It was found that heparin solubilized esterase activity from ligated nerves. Sedimentation analysis revealed this activity to be mainly the 16S form. Chondroitin sulphate did not solubilize AChE activity, and protamine eliminated the solubilizing effect. Our results suggest the involvement of sulphated glycosaminoglycans in the intra-axonal localization and transport of 16S AChE.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1983 PMID： 6626175 PMCID： PMC1152381 DOI： 10.1042/bj2150201

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

22 in total

Review 1. Chemistry and pharmacology of heparin.

Authors: J Ehrlich; S S Stivala
Journal: J Pharm Sci Date: 1973-04 Impact factor: 3.534

2. Rapid axonal transport in vitro in the sciatic system of the frog of fucose-, glucosamine- and sulphate-containing material.

Authors: A Edström; H Mattsson
Journal: J Neurochem Date: 1972-07 Impact factor: 5.372

3. Fast axoplasmic transport of acetylcholinesterase in mammalian nerve fibres.

Authors: N Ranish; S Ochs
Journal: J Neurochem Date: 1972-11 Impact factor: 5.372

4. Rapid axonal transport of sulfated mucopolysaccharide proteins.

Authors: J S Elam; J M Goldberg; N S Radin; B W Agranoff
Journal: Science Date: 1970-10-23 Impact factor: 47.728

5. Multiple forms of acetylcholinesterase and their distribution in endplate and non-endplate regions of rat diaphragm muscle.

Authors: Z W Hall
Journal: J Neurobiol Date: 1973

6. Solubilization by heparin of the phospholipase A1 from the plasma membranes of rat liver.

Authors: M Waite; P Sisson
Journal: J Biol Chem Date: 1973-10-25 Impact factor: 5.157

7. Acetylcholinesterase transport in the central and peripheral nervous tissue: the role of tubules in the enzyme transport.

Authors: P Kasa
Journal: Nature Date: 1968-06-29 Impact factor: 49.962

3. Acetylcholinesterase expression in muscle is specifically controlled by a promoter-selective enhancesome in the first intron.

Authors: Shelley Camp; Antonella De Jaco; Limin Zhang; Michael Marquez; Brian De la Torre; Palmer Taylor
Journal: J Neurosci Date: 2008-03-05 Impact factor: 6.167

3 in total

Neural 16S acetylcholinesterase is solubilized by heparin.

Review 1. Chemistry and pharmacology of heparin.

2. Rapid axonal transport in vitro in the sciatic system of the frog of fucose-, glucosamine- and sulphate-containing material.

3. Fast axoplasmic transport of acetylcholinesterase in mammalian nerve fibres.

4. Rapid axonal transport of sulfated mucopolysaccharide proteins.

5. Multiple forms of acetylcholinesterase and their distribution in endplate and non-endplate regions of rat diaphragm muscle.

6. Solubilization by heparin of the phospholipase A1 from the plasma membranes of rat liver.

7. Acetylcholinesterase transport in the central and peripheral nervous tissue: the role of tubules in the enzyme transport.

8. The fluid mosaic model of the structure of cell membranes.

9. Axonal microtubules and associated filaments stained by Alcian blue.

10. Substructure of microtubules in brain nerve cells as revealed by ruthenium red.

1. Binding of the asymmetric forms of acetylcholinesterase to heparin.

2. Asymmetric acetylcholinesterase is assembled in the Golgi apparatus.

3. Acetylcholinesterase expression in muscle is specifically controlled by a promoter-selective enhancesome in the first intron.