Literature DB >> 6625650

Percutaneous penetration of hydrocortisone in humans following skin delipidization by 1:1:1 trichloroethane.

D A Bucks, H I Maibach, E Menczel, R C Wester.   

Abstract

The effect of skin delipidization in humans on the percutaneous penetration of hydrocortisone was investigated in a cross-over trial. The delipidizing agent was 1:1:1 trichloroethane, a common industrial organic solvent. The findings do not show any significant difference in the topical absorption of hydrocortisone with and without skin delipidization. It was postulated that the natural skin barrier was reestablished by the metabolic cutaneous lipid regeneration concomitant with the absorption of the fatty ingredients from the cream.

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Year:  1983        PMID： 6625650     DOI： 10.1007/bf00416669

Source DB:  PubMed          Journal:  Arch Dermatol Res        ISSN： 0340-3696            Impact factor:   3.017


  16 in total

1.  The water barrier in human epidermis. Physical and chemical nature.

Authors:  H D ONKEN; C A MOYER
Journal:  Arch Dermatol       Date:  1963-05

2.  The transport of water through the human epidermis.

Authors:  J W MALI
Journal:  J Invest Dermatol       Date:  1956-12       Impact factor: 8.551

3.  Method of preparation and application of small quantities of semi-solid topicals.

Authors:  C Lindsay; R Feldmann; H Maibach
Journal:  Arch Dermatol Res       Date:  1976-11-26       Impact factor: 3.017

4.  Studies of diffusion of water through dead human skin; the effect of different environmental states and of chemical alterations of the epidermis.

Authors:  G S BERENSON; G E BURCH
Journal:  Am J Trop Med Hyg       Date:  1951-11       Impact factor: 2.345

5.  Influence of solvents and surface active agents on the barrier function of the skin towards Sarin. II. Increase in rate of absorption.

Authors:  T Fredriksson
Journal:  Acta Derm Venereol       Date:  1969       Impact factor: 4.437

6.  Methyl chloroform intoxication. Diagnosis and treatment.

Authors:  R D Stewart
Journal:  JAMA       Date:  1971-03-15       Impact factor: 56.272

7.  Isolation and lipid biochemical characterization of stratum corneum membrane complexes: implications for the cutaneous permeability barrier.

Authors:  S Grayson; P M Elias
Journal:  J Invest Dermatol       Date:  1982-02       Impact factor: 8.551

Review 8.  Permeability of the skin.

Authors:  R J Scheuplein; I H Blank
Journal:  Physiol Rev       Date:  1971-10       Impact factor: 37.312

9.  Mechanism of percutaneous absorption. 3. The effect of temperature on the transport of non-electrolytes across the skin.

Authors:  I H Blank; R J Scheuplein; D J MacFarlane
Journal:  J Invest Dermatol       Date:  1967-12       Impact factor: 8.551

10.  Effect of lipids on the aggregation and permeability of human stratum corneum.

Authors:  W P Smith; M S Christensen; S Nacht; E H Gans
Journal:  J Invest Dermatol       Date:  1982-01       Impact factor: 8.551
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  3 in total

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Authors:  Sanja Kezic; J B Nielsen
Journal:  Int Arch Occup Environ Health       Date:  2009-02-24       Impact factor: 3.015

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Authors:  Sharan R Srinivasan; Vikram G Shakkottai
Journal:  Neurotherapeutics       Date:  2019-10       Impact factor: 7.620

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Journal:  Neurotherapeutics       Date:  2019-10       Impact factor: 7.620
  3 in total

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