Literature DB >> 6624880

Enhancement of human polymorphonuclear leukocyte adherence by the phospholipid mediator 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC).

F H Valone, E J Goetzl.   

Abstract

The phospholipid mediator 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC) increases human polymorphonuclear leukocyte (PMN) adherence to Sephadex G-25 in manner directly proportional to the concentration of AGEPC from 2 to 650 nM. The maximal enhancement of PMN adherence of 85% +/- 23% (mean +/- SD) evoked by 650 nM AGEPC was indistinguishable in magnitude from that elicited by an optimal concentration of the chemotactic peptide N-f-Met-Leu-Phe. The results of analyses of the relative PMN adherence-enhancing activities of analogs of AGEPC suggest distinct molecular requirements for the enhancement of adherence. PMN adherence increases within 1 minute after exposure of the leukocytes to AGEPC, and the augmented adherence persists for over 30 minutes in spite of extensive washing of the leukocytes. Indomethacin partially blocked enhancement of adherence by AGEPC, suggesting that thromboxane A2 mediates in part the enhancement of adherence by AGEPC.

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Year:  1983        PMID： 6624880      PMCID： PMC1916290     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  16 in total

1.  The effect of anti-inflammatory agents and inflammation on granulocyte adherence. Evidence for regulation by plasma factors.

Authors:  R R MacGregor
Journal:  Am J Med       Date:  1976-11       Impact factor: 4.965

2.  The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor.

Authors:  A L Lentnek; A D Schreiber; R R MacGregor
Journal:  J Clin Invest       Date:  1976-04       Impact factor: 14.808

3.  Antihypertensive activity of an alkyl ether analog of phosphatidylcholine.

Authors:  M L Blank; F Snyder; L W Byers; B Brooks; E E Muirhead
Journal:  Biochem Biophys Res Commun       Date:  1979-10-29       Impact factor: 3.575

4.  Novel effects of 1-O-hexadecyl-2-acyl-sn-glycero-3-phosphorycholine mediators on human leukocyte function: delineation of the specific roles of the acyl substituents.

Authors:  E J Goetzl; C K Derian; A I Tauber; F H Valone
Journal:  Biochem Biophys Res Commun       Date:  1980-06-16       Impact factor: 3.575

5.  The immunological generation of a platelet-activating factor and a platet-lytic factor in the rat.

Authors:  F H Valone; D I Whitmer; W C Pickett; K F Austen; E J Goetzl
Journal:  Immunology       Date:  1979-08       Impact factor: 7.397

6.  Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

Authors:  C A Demopoulos; R N Pinckard; D J Hanahan
Journal:  J Biol Chem       Date:  1979-10-10       Impact factor: 5.157

7.  Modulating influence of chemotactic factor-induced cell adhesiveness on granulocyte function.

Authors:  J Fehr; C Dahinden
Journal:  J Clin Invest       Date:  1979-07       Impact factor: 14.808

8.  Thromboxane A2 mediates augmented polymorphonuclear leukocyte adhesiveness.

Authors:  P J Spagnuolo; J J Ellner; A Hassid; M J Dunn
Journal:  J Clin Invest       Date:  1980-09       Impact factor: 14.808

9.  Activation and desensitization of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. I. Characteristics of the secretory response.

Authors:  P M Henson
Journal:  J Exp Med       Date:  1976-04-01       Impact factor: 14.307

10.  Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor.

Authors:  J Benveniste; P M Henson; C G Cochrane
Journal:  J Exp Med       Date:  1972-12-01       Impact factor: 14.307
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  6 in total

1.  A neutrophil-derived cytochrome P450-dependent metabolite of arachidonic acid modulates neutrophil behavior.

Authors:  R Kraemer; M M Bednar; M A Hatala; K M Mullane
Journal:  Am J Pathol       Date:  1987-09       Impact factor: 4.307

2.  Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit.

Authors:  L M McManus; R N Pinckard
Journal:  Am J Pathol       Date:  1985-10       Impact factor: 4.307

3.  Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine.

Authors:  F H Valone
Journal:  Immunology       Date:  1984-05       Impact factor: 7.397

4.  Platelet activating factor amplifies human neutrophil adherence to bovine endothelial cells: evidence for a lipoxygenase dependent mechanism.

Authors:  B Damtew; P J Spagnuolo
Journal:  Inflammation       Date:  1992-10       Impact factor: 4.092

5.  Preferential human eosinophil chemotactic activity of the platelet-activating factor (PAF) 1-0-hexadecyl-2-acetyl-sn-glyceryl-3-phosphocholine (AGEPC).

Authors:  C E Sigal; F H Valone; M J Holtzman; E J Goetzl
Journal:  J Clin Immunol       Date:  1987-03       Impact factor: 8.317

6.  Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes.

Authors:  J Lefkowith; G Schreiner; J Cormier; E S Handler; H K Driscoll; D Greiner; J P Mordes; A A Rossini
Journal:  J Exp Med       Date:  1990-03-01       Impact factor: 14.307
  6 in total

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