Localization of 1,6-[14C]diaminohexane (HMDA) in the prostate and the effects of HMDA on early gestation in Fischer-344 rats.

Following oral administration of 1,6-[14C]diaminohexane (hexamethylenediamine, HMDA) to male Fischer-344 rats, approx. 20% of the administered dose was recovered as 14CO2 after 72 h. Urinary and fecal excretion accounted for 47% and 27% of the administered radioactivity, respectively. Of several tissues examined, the highest concentrations of residual radioactivity were found in the prostate at 24 and 72 h post-administration. Daily administration of HMDA (200 mg/kg/day) by gavage to pregnant female rats for 2 weeks starting on gestation day 0 did not affect litter size in these animals.