Literature DB >> 6623146

Profound neutropenia associated with benzylpenicillin.

S R Snavely, J H Helzberg, D C Bodensteiner, F V Plapp, J W Davis, G R Hodges.   

Abstract

A 31-year-old white man with suspected aspiration pneumonia complicated by multiple pulmonary abscesses had profound neutropenia during a course of high-dose benzylpenicillin therapy for suspected bacterial endocarditis. Antigranulocyte antibodies were identified in the patient's serum. Leukopenia is an uncommon but potentially serious complication of therapy with this drug. We recommend weekly monitoring of blood counts during prolonged therapy with any beta-lactam antibiotic.

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Year:  1983        PMID: 6623146     DOI: 10.1097/00007611-198310000-00026

Source DB:  PubMed          Journal:  South Med J        ISSN: 0038-4348            Impact factor:   0.954


  2 in total

1.  Penicillin-induced agranulocytosis.

Authors:  B Walz; J Zupnick; D Uden; A Keating
Journal:  West J Med       Date:  1988-10

2.  Neutropenia induced by high-dose intravenous benzylpenicillin in treating neurosyphilis: Does it really matter?

Authors:  Rui-Rui Peng; Juan Wu; Wei Zhao; Tengfei Qi; Mei Shi; Zhifang Guan; Haikong Lu; Fuquan Long; Zixiao Gao; Sufang Zhang; Pingyu Zhou
Journal:  PLoS Negl Trop Dis       Date:  2017-03-13
  2 in total

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