Literature DB >> 6623064

Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.

S D Bernal, T J Lampidis, R M McIsaac, L B Chen.   

Abstract

Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.

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Year:  1983        PMID： 6623064     DOI： 10.1126/science.6623064

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  35 in total

1.  p53-independent inhibition of proliferation and p21(WAF1/Cip1)-modulated induction of cell death by the antioxidants N-acetylcysteine and vitamin E.

Authors:  J L Nargi; R R Ratan; D E Griffin
Journal:  Neoplasia       Date:  1999-12       Impact factor: 5.715

2.  Metabolism and elimination of rhodamine 123 in the rat.

Authors:  T W Sweatman; R Seshadri; M Israel
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

3.  Selective photodepletion of malignant T cells in extracorporeal photopheresis with selenorhodamine photosensitizers.

Authors:  Zachariah A McIver; Mark W Kryman; Young Choi; Benjamin N Coe; Gregory A Schamerhorn; Michelle K Linder; Kellie S Davies; Jacqueline E Hill; Geri A Sawada; Jason M Grayson; Michael R Detty
Journal:  Bioorg Med Chem       Date:  2016-06-02       Impact factor: 3.641

4.  A recessive cellular mutation in v-fes-transformed mink cells restores contact inhibition and anchorage-dependent growth.

Authors:  J R Haynes; J R Downing
Journal:  Mol Cell Biol       Date:  1988-06       Impact factor: 4.272

5.  Mitochondria in living cells cultured from human chorionic villi: the effects of colchicine on numbers and distribution.

Authors:  F K Addai; C D Ockleford
Journal:  J Anat       Date:  1986-08       Impact factor: 2.610

Review 6.  From delocalized lipophilic cations to hypoxia: blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors.

Authors:  Metin Kurtoglu; Theodore J Lampidis
Journal:  Mol Nutr Food Res       Date:  2009-01       Impact factor: 5.914

7.  Active cell membrane mechanisms involved in the exclusion of Rh 123 allow distinction between normal and tumoral cells.

Authors:  G Lizard; M C Chignol; Y Chardonnet; D Schmitt
Journal:  Cell Biol Toxicol       Date:  1994-12       Impact factor: 6.691

8.  Cationic drug analysis using matrix-assisted laser desorption/ionization mass spectrometry: application to influx kinetics, multidrug resistance, and intracellular chemical change.

Authors:  D Rideout; A Bustamante; G Siuzdak
Journal:  Proc Natl Acad Sci U S A       Date:  1993-11-01       Impact factor: 11.205

9.  Dequalinium, a topical antimicrobial agent, displays anticarcinoma activity based on selective mitochondrial accumulation.

Authors:  M J Weiss; J R Wong; C S Ha; R Bleday; R R Salem; G D Steele; L B Chen
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

10.  The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis.

Authors:  Giuseppe Filomeni; Sara Piccirillo; Ilaria Graziani; Simone Cardaci; Ana M Da Costa Ferreira; Giuseppe Rotilio; Maria R Ciriolo
Journal:  Carcinogenesis       Date:  2009-04-30       Impact factor: 4.944
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