Literature DB >> 662280

Dipivalyl epinephrine: a new pro-drug in the treatment of glaucoma.

A I Mandell, F Stentz, A E Kitabchi.   

Abstract

The dansyl chloride technique in conjunction with thin layer chromatography and autoradiography has shown that dipivalyl epinephrine is a pro-drug in the human eye. Dipivalyl epinephrine appears to be a more effective epinephrine compound, in that it penetrates the cornea approximately 17 times greater than epinephrine.

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Year:  1978        PMID: 662280     DOI: 10.1016/s0161-6420(78)35668-2

Source DB:  PubMed          Journal:  Ophthalmology        ISSN: 0161-6420            Impact factor:   12.079


  14 in total

Review 1.  Prodrug strategies in ocular drug delivery.

Authors:  Megha Barot; Mahuya Bagui; Mitan R Gokulgandhi; Ashim K Mitra
Journal:  Med Chem       Date:  2012-07       Impact factor: 2.745

Review 2.  Ocular drug delivery. Pharmacokinetic considerations.

Authors:  R D Schoenwald
Journal:  Clin Pharmacokinet       Date:  1990-04       Impact factor: 6.447

Review 3.  Targeted Ocular Drug Delivery with Pharmacokinetic/Pharmacodynamic Considerations.

Authors:  Jie Shen; Guang Wei Lu; Patrick Hughes
Journal:  Pharm Res       Date:  2018-09-25       Impact factor: 4.200

Review 4.  Pharmacological therapy for glaucoma: a review.

Authors:  P F Hoyng; L M van Beek
Journal:  Drugs       Date:  2000-03       Impact factor: 9.546

Review 5.  Prodrugs. Do they have advantages in clinical practice?

Authors:  V J Stella; W N Charman; V H Naringrekar
Journal:  Drugs       Date:  1985-05       Impact factor: 9.546

Review 6.  A risk-benefit assessment of drugs used in the management of glaucoma.

Authors:  T Taniguchi; Y Kitazawa
Journal:  Drug Saf       Date:  1994-07       Impact factor: 5.606

Review 7.  Management of glaucoma: focus on pharmacological therapy.

Authors:  Robert E Marquis; Jess T Whitson
Journal:  Drugs Aging       Date:  2005       Impact factor: 3.923

Review 8.  Clinical significance of esterases in man.

Authors:  F M Williams
Journal:  Clin Pharmacokinet       Date:  1985 Sep-Oct       Impact factor: 6.447

9.  A single-blind randomised trial comparing adrenaline 1.0% with dipivalyl epinephrine (propine) 0.1% in the treatment of open-angle glaucoma and ocular hypertension.

Authors:  K B Mills; N A Jacobs
Journal:  Br J Ophthalmol       Date:  1988-06       Impact factor: 4.638

10.  Recent advances in pharmacotherapy of glaucoma.

Authors:  S K Gupta; Galpalli Niranjan D; S S Agrawal; Sushma Srivastava; Rohit Saxena
Journal:  Indian J Pharmacol       Date:  2008-10       Impact factor: 1.200

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